Yazar "Gul, Melek" için listeleme
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alpha-Amination and the 5-exo-trig cyclization reaction of sulfur-containing Schiff bases with N-phenyltriazolinedione and their anti-lipid peroxidation activity
Pelit, Emel; Oikonomou, Kosmas; Gul, Melek; Georgiou, Dimitra; Szafert, Slawomir; Katsamakas, Sotirios; Hadjipavlou-Litina, Dimitra; Elemes, Yiannis (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017)Triazolinedione quenches efficiently the 1,2-dipoles from Schiff bases of glycine esters which are formed via a [1,2-H]-prototropic shift of their alpha-hydrogens, and affords the respective alpha-aminated products in good ... -
Antioxidant and Cytotoxic Activity Studies of Sulfur Containing Glycine Imine Derivatives MCF-7 and DLD-1 Cell Lines
Mesci, Seda; Gul, Melek; Yildirim, Tuba (Marmara Univ, Inst Health Sciences, 2021)Objective: To investigate the antioxidant and cytotoxic activities of sulfur-containing glycine imine derivatives MCF-7 (human breast adenocarcinoma) and DLD-1 (colorectal adenocarcinoma) cell lines. Methods: This study ... -
Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole Derivatives
Ayar, Arif; Aksahin, Masuk; Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: Pyrrole compounds having a heterocyclic structure are the most researched and biological activities such as antioxidant and anticancer activities. Objective: Herein is a first effort to study the significance ... -
Application of organic photovoltaic cell: poly(2-aminofluoren)/multi-walled carbon nanotube composites
Baldemir, Muhammmet Abdullah; Topuksak, Hanife; Tas, Recep; Gul, Melek; Canimkurbey, Betul (Springer, 2021)This work presents the 2-aminofluorene polymer matrix based on the multi-walled carbon nanotube module for an alternative energy conversion system as a photovoltaic solar cell. The properties of the MWCNT-PAF composite ... -
Assessment of Antioxidant Activity of Giant Snowdrop (Galanthus elwesii Hook) Extracts with Their Total Phenol and Flavonoid Contents
Ay, Ebru Bati; Gul, Melek; Acikgoz, M. Akif; Yarilgac, Tarik; Kara, S. Metin (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2018)Background: The aim of this study was to determine total phenolic and flavonoid contents and antioxidant activities of Giant Snowdrop (Galanthus elwesii Hook). Objective: Giant Snowdrop, the second most common snowdrop in ... -
Evaluation of phytochemical content, antioxidant, antimicrobial activity and DNA cleavage effect of endemic Linaria corifolia Desf. (Plantaginaceae)
Gul, Melek; Cali, Ilkay Ozturk; Cansaran, Arzu; Idil, Onder; Kulu, Irem; Celikoglu, Umut (TAYLOR & FRANCIS AS, 2017)The aim of this study is to isolate Linaria corifolia Desf. (Plantaginaceae) and identify new apigenine derivatives 6,3'-dimethoxyapigenin-7-O-[(rhamnosyl)-(1-2)-6.-acetyl glucoside]. Moreover, we analyzed biological ... -
Hydroarylation reactions of N-acylaminosubstituted tricyclic imides
Gul, Melek; Kulu, Irem; Ocal, Nuket (SCIENCE REVIEWS 2000 LTD, 2013)The palladium-catalysed hydroarylation of unsaturated N-acylamino-substituted tricyclic imides provided a new stereoselective synthesis of exo-aryl(heteroaryl)-substituted tricyclic N-acylamino imides. -
Investigation of antioxidant activity and effect on cell viability of pyrrolidine compounds in MCF-7 (breast cancer) and DLD-1 (colon cancer) cell lines
Mesci, Seda; Gul, Melek; Yildirm, Tuba (Al-Farabi Kazakh Natl Univ, 2021)In this study, it is aimed to investigate the effects of pyrrolidine compounds that are thought to be new drug candidates with effect on cell viability on cancer (MCF-7 and DLD-1) and normal (MCF-12A and CCD-18CO) cell ... -
Isoxazole derivatives of alpha-pinene isomers: Synthesis, crystal structure, spectroscopic characterization (FT-IR/NMR/GC-MS) and DFT studies
Eryilmaz, Serpil; Gul, Melek; Inkaya, Ersin; Tas, Murat (ELSEVIER SCIENCE BV, 2016)In this paper, the alpha-pinene isoxazole derivatives (3a-b-c, 4a-b) were synthesized via 1,3-dipolar cycloaddition and characterized with FT-IR, H-1 NMR, C-13 NMR and GC MS. Isoxazole (C21H23NO) compound (4a) 6,6,7a,-tr ... -
A Multidisciplinary Approach to Coronavirus Disease (COVID-19)
Erturk, Aliye Gediz; Sahin, Arzu; Ay, Ebru Bati; Pelit, Emel; Bagdatli, Emine; Kulu, Irem; Gul, Melek (Mdpi, 2021)Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority ... -
Phenolic Compound, Flavonoid and Antioxidant Activity of Merzifon Black Grape Variety (Vitis vinifera L.)
Kurt, Gulhan; Ozturk, Ilkay; Gul, Melek (Kahramanmaras Sutcu Imam Univ Rektorlugu, 2023)In this study, it was aimed to determine the phenolic compound, flavonoid and antioxidant activity of the Merzifon Black grape variety (Vitis vinifera L.). The antioxidant activity, total phenolic compound and total flavonoid ... -
PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT, ANTIMICROBIAL ACTIVITY AND DNA INTERACTION OF LEUCOJUM AESTIVUM
Hundur, Dilber Ozgun; Idil, Onder; Kandemir, Nezahat; Gul, Melek; Konar, Vahit (PARLAR SCIENTIFIC PUBLICATIONS (P S P), 2018)The aim of this study was evaluation of in-vitro antioxidant and antimicrobial activities of Leucojum aestivum extracts, and determination of the total phenolic compounds of Leucojum aestivum by reverse-phase high-performance ... -
Synthesis of PhTAD-substituted dihydropyrrole derivatives via stereospecific C-H amination
Gul, Melek; Elemes, Yiannis; Pelit, Emel; Dernektsi, Eleni; Georgiou, Dimitra; Oikonomou, Kosmas; Lis, Tadeusz; Szafert, Slawomir (SPRINGER, 2017)Stereospecific alpha-amination has been accomplished via addition of N-phenyltriazolinedione (PhTAD) to the allylic position of dihydropyrroles. The aim of this study is to evaluate new PhTAD derivatives of biologically ... -
Synthesis of Spirocyclic and Tricyclic Isoxazoline via 1,3-Dipolar Cycloaddition Reactions
Gul, Melek; Tutar, Ahmet (WILEY-BLACKWELL, 2014)1,3-Dipolar cycloadditions of the bicyclic monoterpenes (S)-(-)-camphene (1), (R)-(+)-a-pinene (2), and (S)-(-)-b-pinene (3) with aryl and heteroaryl nitrile oxides afforded new spirocyclic and tricyclic isoxazoline ... -
Synthesis, antimicrobial activity and molecular docking studies of spiroquinoline-indoline-dione and spiropyrazolo-indoline-dione derivatives
Gul, Melek; Celikoglu, Emine Turk; Idil, Onder; Tas, Gamze; Pelit, Emel (Nature Portfolio, 2023)Spiro[benzo[h]quinoline-7,3 '-indoline]diones and spiro[indoline-3,4 '-pyrazolo[3,4-b]quinoline]diones were efficiently synthesized via one-pot multi-component reactions under ultrasound-promoted conditions. Spiro[benzo[ ... -
Synthesis, Antioxidant Activity and Theoretical Investigation of Isoxazolines Derivatives of Monoterpenoids
Gul, Melek; Eryilmaz, Scrpil (BENTHAM SCIENCE PUBL LTD, 2019)The 3+2 cycloaddition reactions are important to generate five-membered heterocyclic compounds as well as altering biological activity effects based on structure. In the study, we synthesized new isoxazoline derivatives ... -
Synthesis, crystal structure analysis, spectral characterization, quantum chemical calculations, antioxidant and antimicrobial activity of 3-(4-chlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methanobenzo[d]isoxazole
Eryilmaz, Serpil; Gul, Melek; Inkaya, Ersin; Idil, Onder; Ozdemir, Namik (ELSEVIER SCIENCE BV, 2016)In this paper, 3-(4-chlorophenyl)-3a,4,7,7a-tetrahydro-4,7-methanobenzo[d]isoxazole was synthesized via 1,3 dipolar cycloaddition, characterized by spectroscopic analysis such as FT-IR, H-1 NMR, C-13 NMR, UV-Vis, LC-MS/MS, ...
