Yazar "Gul, Melek" için listeleme
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1,3-Naphthoxazine derivatives: Synthesis, in silico pharmacokinetic studies, antioxidant and photoprotective properties
Pelit, Emel; Erturk, Aliye Gediz; Gul, Melek (Academic Press Inc Elsevier Science, 2024)Investigation into the interactions between photoprotective agents and skin can offer a precise understanding of their biological behaviors in vitro and in vivo, providing crucial insights for generating new substances. ... -
alpha-Amination and the 5-exo-trig cyclization reaction of sulfur-containing Schiff bases with N-phenyltriazolinedione and their anti-lipid peroxidation activity
Pelit, Emel; Oikonomou, Kosmas; Gul, Melek; Georgiou, Dimitra; Szafert, Slawomir; Katsamakas, Sotirios; Hadjipavlou-Litina, Dimitra; Elemes, Yiannis (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017)Triazolinedione quenches efficiently the 1,2-dipoles from Schiff bases of glycine esters which are formed via a [1,2-H]-prototropic shift of their alpha-hydrogens, and affords the respective alpha-aminated products in good ... -
Antioxidant and Cytotoxic Activity Studies of Sulfur Containing Glycine Imine Derivatives MCF-7 and DLD-1 Cell Lines
Mesci, Seda; Gul, Melek; Yildirim, Tuba (Marmara Univ, Inst Health Sciences, 2021)Objective: To investigate the antioxidant and cytotoxic activities of sulfur-containing glycine imine derivatives MCF-7 (human breast adenocarcinoma) and DLD-1 (colorectal adenocarcinoma) cell lines. Methods: This study ... -
Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole Derivatives
Ayar, Arif; Aksahin, Masuk; Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: Pyrrole compounds having a heterocyclic structure are the most researched and biological activities such as antioxidant and anticancer activities. Objective: Herein is a first effort to study the significance ... -
Application of organic photovoltaic cell: poly(2-aminofluoren)/multi-walled carbon nanotube composites
Baldemir, Muhammmet Abdullah; Topuksak, Hanife; Tas, Recep; Gul, Melek; Canimkurbey, Betul (Springer, 2021)This work presents the 2-aminofluorene polymer matrix based on the multi-walled carbon nanotube module for an alternative energy conversion system as a photovoltaic solar cell. The properties of the MWCNT-PAF composite ... -
Assessment of Antioxidant Activity of Giant Snowdrop (Galanthus elwesii Hook) Extracts with Their Total Phenol and Flavonoid Contents
Ay, Ebru Bati; Gul, Melek; Acikgoz, M. Akif; Yarilgac, Tarik; Kara, S. Metin (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2018)Background: The aim of this study was to determine total phenolic and flavonoid contents and antioxidant activities of Giant Snowdrop (Galanthus elwesii Hook). Objective: Giant Snowdrop, the second most common snowdrop in ... -
Downregulation of HSP27 by isoindole-derived pyrrolidines suppressing multidrug resistance (MDR) and inducing apoptosis in MCF-7 and DLD-1 cell lines
Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Natl Inst Science Communication-Niscair, 2024)In most cancer treatments, major problem arises from the prevention of cell death (apoptosis suppression) with the development of drug resistance. Anticancer agents that ensure elimination of drug resistance and drug-resistant ... -
Evaluation of Novel Hydrazone-Imide Hybrid Compound as HNE Inhibitor In Silico: Synthesis, XRD and DFT Analysis
Eryilmaz, Serpil; Gul, Melek; Yildirim, Arzu Ozek (Wiley-V C H Verlag Gmbh, 2024)Investigation into the interactions between drugs and biomolecules can offer a precise understanding of their biological behaviours in vitro and in vivo, providing crucial insights for designing new drugs. Herein, we report ... -
Evaluation of phytochemical content, antioxidant, antimicrobial activity and DNA cleavage effect of endemic Linaria corifolia Desf. (Plantaginaceae)
Gul, Melek; Cali, Ilkay Ozturk; Cansaran, Arzu; Idil, Onder; Kulu, Irem; Celikoglu, Umut (TAYLOR & FRANCIS AS, 2017)The aim of this study is to isolate Linaria corifolia Desf. (Plantaginaceae) and identify new apigenine derivatives 6,3'-dimethoxyapigenin-7-O-[(rhamnosyl)-(1-2)-6.-acetyl glucoside]. Moreover, we analyzed biological ... -
Examination of Triazolinedione-Derived Dihydropyrrole Hybrid Compounds: ER Stress-Related Apoptosis in Breast Cancer Cells, Molecular Docking, and ADMET Analysis
Mesci, Seda; Ayar, Arif; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2024)Background In many types of cancer, uncontrolled growth and proliferation of cells occur due to abnormalities in their genes, mutations of pro-apoptotic proteins, or upregulation of anti-apoptotic proteins. Triazolinedione ... -
Green Synthesis of Spiroindole Derivatives: Biological Evaluation and in Silico Studies
Pelit, Emel; Celikoglu, Umut; Gul, Melek (Taylor & Francis Ltd, 2024)This work describes the synthesis of spiro derivative compounds in the presence of nonmetallic catalysts and ultrasonic irradiation. These synthesized derivatives constitute an important class of organic compounds and ... -
Hydroarylation reactions of N-acylaminosubstituted tricyclic imides
Gul, Melek; Kulu, Irem; Ocal, Nuket (SCIENCE REVIEWS 2000 LTD, 2013)The palladium-catalysed hydroarylation of unsaturated N-acylamino-substituted tricyclic imides provided a new stereoselective synthesis of exo-aryl(heteroaryl)-substituted tricyclic N-acylamino imides. -
Investigation of antioxidant activity and effect on cell viability of pyrrolidine compounds in MCF-7 (breast cancer) and DLD-1 (colon cancer) cell lines
Mesci, Seda; Gul, Melek; Yildirm, Tuba (Al-Farabi Kazakh Natl Univ, 2021)In this study, it is aimed to investigate the effects of pyrrolidine compounds that are thought to be new drug candidates with effect on cell viability on cancer (MCF-7 and DLD-1) and normal (MCF-12A and CCD-18CO) cell ... -
Isoxazole derivatives of alpha-pinene isomers: Synthesis, crystal structure, spectroscopic characterization (FT-IR/NMR/GC-MS) and DFT studies
Eryilmaz, Serpil; Gul, Melek; Inkaya, Ersin; Tas, Murat (ELSEVIER SCIENCE BV, 2016)In this paper, the alpha-pinene isoxazole derivatives (3a-b-c, 4a-b) were synthesized via 1,3-dipolar cycloaddition and characterized with FT-IR, H-1 NMR, C-13 NMR and GC MS. Isoxazole (C21H23NO) compound (4a) 6,6,7a,-tr ... -
A Multidisciplinary Approach to Coronavirus Disease (COVID-19)
Erturk, Aliye Gediz; Sahin, Arzu; Ay, Ebru Bati; Pelit, Emel; Bagdatli, Emine; Kulu, Irem; Gul, Melek (Mdpi, 2021)Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority ... -
Novel alkyne chromophore of the isophorone derivatives: synthesis, electrochemical evaluation, DFT, and processable bottom contact/top-gate OFET applications
Canimkurbey, Betul; Kir, Merve Nur Kamsiz; Eryilmaz, Serpil; Gul, Melek (Springer, 2024)Fused alkyne molecules are important in organic semiconductors due to their desirable properties. Here, we report the design and synthesis of a new series of A-pi-D molecules (III-VII) that can serve as mild electron ... -
Phenolic Compound, Flavonoid and Antioxidant Activity of Merzifon Black Grape Variety (Vitis vinifera L.)
Kurt, Gulhan; Ozturk, Ilkay; Gul, Melek (Kahramanmaras Sutcu Imam Univ Rektorlugu, 2023)In this study, it was aimed to determine the phenolic compound, flavonoid and antioxidant activity of the Merzifon Black grape variety (Vitis vinifera L.). The antioxidant activity, total phenolic compound and total flavonoid ... -
PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT, ANTIMICROBIAL ACTIVITY AND DNA INTERACTION OF LEUCOJUM AESTIVUM
Hundur, Dilber Ozgun; Idil, Onder; Kandemir, Nezahat; Gul, Melek; Konar, Vahit (PARLAR SCIENTIFIC PUBLICATIONS (P S P), 2018)The aim of this study was evaluation of in-vitro antioxidant and antimicrobial activities of Leucojum aestivum extracts, and determination of the total phenolic compounds of Leucojum aestivum by reverse-phase high-performance ... -
Pyrazolone-based charge transport materials: Design, synthesis, DFT predictions, and application in organic solar cell
Eryilmaz, Serpil; Gul, Melek; Canimkurbey, Betul (Elsevier, 2025)This study presents the design and synthesis of new pyrazolone-based materials featuring anthracene, pyrazolone, fluorene, and pyrene terminal groups, utilizing a cost-efficient synthetic route through HATU-assisted amide ... -
Synthesis of PhTAD-substituted dihydropyrrole derivatives via stereospecific C-H amination
Gul, Melek; Elemes, Yiannis; Pelit, Emel; Dernektsi, Eleni; Georgiou, Dimitra; Oikonomou, Kosmas; Lis, Tadeusz; Szafert, Slawomir (SPRINGER, 2017)Stereospecific alpha-amination has been accomplished via addition of N-phenyltriazolinedione (PhTAD) to the allylic position of dihydropyrroles. The aim of this study is to evaluate new PhTAD derivatives of biologically ...
