| dc.contributor.author | Yildirim, Tuba | |
| dc.contributor.author | Senkuytu, Elif | |
| dc.contributor.author | Ergene, Emel | |
| dc.contributor.author | Bilgin, Kemal | |
| dc.contributor.author | Uludag, Yildiz | |
| dc.contributor.author | Ciftci, Gonul Yenilmez | |
| dc.date.accessioned | 2019-09-01T13:04:15Z | |
| dc.date.available | 2019-09-01T13:04:15Z | |
| dc.date.issued | 2018 | |
| dc.identifier.issn | 2365-6549 | |
| dc.identifier.uri | https://dx.doi.org/10.1002/slct.201801766 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12450/863 | |
| dc.description | WOS: 000444538800024 | en_US |
| dc.description.abstract | In this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass spectrometry, H-1, P-31 NMR techniques. Later, the effects of the synthesized compounds to DNA were screened using DNA interaction analysis and cleavage methods by utilizing pUC18 plasmid. The results showed that the compounds 14, 40 and 45 caused Form III (linearized DNA) plasmid DNA, indicating the interaction of these compounds with the plasmid DNA. | en_US |
| dc.description.sponsorship | Scientific and Technical Research Council of Turkey (TUBITAK) [111T085] | en_US |
| dc.description.sponsorship | The authors thank to the Scientific and Technical Research Council of Turkey (TUBITAK) (Grant no: 111T085) for financial support. We gratefully acknowledge AUMAULAB laboratory in Amasya University (Turkey) for their contribution to the biological activity tests. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
| dc.relation.isversionof | 10.1002/slct.201801766 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Biological Activity | en_US |
| dc.subject | Cyclophosphazen | en_US |
| dc.subject | DNA Binding | en_US |
| dc.subject | Fluorenylidene | en_US |
| dc.subject | Phosphazene | en_US |
| dc.title | Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes | en_US |
| dc.type | article | en_US |
| dc.relation.journal | CHEMISTRYSELECT | en_US |
| dc.identifier.volume | 3 | en_US |
| dc.identifier.issue | 34 | en_US |
| dc.identifier.startpage | 9933 | en_US |
| dc.identifier.endpage | 9939 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.department-temp | [Yildirim, Tuba] Amasya Univ, Fac Art & Sci, Dept Biol, TR-05100 Amasya, Turkey -- [Senkuytu, Elif -- Ciftci, Gonul Yenilmez] Gebze Tech Univ, Dept Chem, TR-41400 Kocaeli, Turkey -- [Ergene, Emel] Anadolu Univ, Dept Biol, TR-26470 Eskisehir, Turkey -- [Bilgin, Kemal] Ondokuz Mayis Univ, Vacat Higher Sch Hlth Serv, Dept Med Serv & Tech, TR-55139 Samsun, Turkey -- [Uludag, Yildiz] UEKAE BILGEM Sci & Technol Res Council Turkey TUB, Bioelect Devices & Syst Grp, TR-41470 Gebze, Turkey | en_US |
