| dc.description.abstract | Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested Hood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested Hood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure. | en_US |
| dc.contributor.department-temp | [Eken, Huseyin -- Cimen, Orhan -- Pehlivanoglu, Kamil] Erzincan Binali Yildirim Univ, Fac Med, Dept Gen Surg, Erzincan, Turkey -- [Cimen, Ferda Keskin] Erzincan Binali Yildirim Univ, Fac Med, Dept Pathol, Erzincan, Turkey -- [Kurnaz, Eray] Mengucek Gazi Training & Res Hosp, Dept Gen Surg, Erzincan, Turkey -- [Yildirim, Murat] Zile State Hosp, Dept Gen Surg, Tokat, Turkey -- [Tasova, Volkan] Amasya Univ, Sabuncuoglu Serafetlin Training & Res Hosp, Dept Gen Surg, Amasya, Turkey -- [Kurt, Nezahat] Ataturk Univ, Fac Med, Dept Biochem, Erzurum, Turkey -- [Onk, Didem] Erzincan Binali Yildirim Univ, Fac Med, Dept Anesthesiol & Reanimat, Erzincan, Turkey -- [Bilgin, Asli Ozbek] Erzincan Binali Yildirim Univ, Fac Med, Dept Pharmacol, Erzincan, Turkey -- [Eken, Huseyin -- Cimen, Orhan -- Cimen, Ferda Keskin -- Kurnaz, Eray -- Yildirim, Murat -- Tasova, Volkan -- Kurt, Nezahat -- Pehlivanoglu, Kamil -- Onk, Didem -- Bilgin, Asli Ozbek] Ataturk Univ, Med Expt Applicat & Res Ctr, Erzurum, Turkey | en_US |
