Adsorptive stripping voltammetric methods for determination of aripiprazole

Abstract

Anodic behavior of aripiprazole (ARP) was studied using electrochemical methods. Charge transfer, diffusion and surface coverage coefficients of adsorbed molecules and the number of electrons transferred in electrode mechanisms were calculated for quasi-reversible and adsorption-controlled electrochemical oxidation of ARP at 1.15 V versus Ag/AgCl at pH 4.0 in Britton-Robinson buffer (BR) on glassy carbon electrode. Voltammetric methods for direct determination of ARP in pharmaceutical dosage forms and biological samples were developed. Linearity range is found as from 11.4 ?M (5.11 mg/L) to 157 ?M (70.41 mg/L) without stripping mode and it is found as from 0.221 ?M (0.10 mg/L) to 13.6 ?M (6.10 mg/L) with stripping mode. Limit of detection (LOD) was found to be 0.11 ?M (0.05 mg/L) in stripping voltammetry. Methods were successfully applied to assay the drug in tablets, human serum and human urine with good recoveries between 95.0% and 104.6% with relative standard deviation less than 10%. © 2012 Xian Jiaotong University. Production and hosting by Elsevier B.V. All rights reserved.