• Türkçe
    • English
  • Türkçe 
    • Türkçe
    • English
  • Giriş
Öğe Göster 
  •   DSpace@Amasya
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • Öğe Göster
  •   DSpace@Amasya
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • Öğe Göster
JavaScript is disabled for your browser. Some features of this site may not work without it.

Do the azo food colorings carmoisine and ponceau 4R have a genotoxic potential?

Erişim

info:eu-repo/semantics/closedAccess

Tarih

2025

Yazar

Kara, Sadriye Gokce
Yuzbasioglu, Deniz
Avuloglu-Yilmaz, Ece
Unal, Fatma

Üst veri

Tüm öğe kaydını göster

Özet

Today, ready-to-eat foods to which various additives are frequently added are widely consumed. Food colorings constitute an essential part of these additives. Carmoisine (E-122) and Ponceau 4R (E-124) are the most commonly used azo food colorings. This study aimed to investigate the in vitro genotoxic effects of these two food dyes in human peripheral lymphocytes using four different and complementary genotoxicity tests (chromosome aberrations (CAs), sister chromatid exchange (SCEs), cytokinesis block micronucleus cytome (CBMN-Cyt) and comet). When four different concentrations (37.5, 75, 150, and 300 mu g/mL) of both food dyes were applied to lymphocytes for 24 and 48 h, it was observed that only the highest concentration significantly increased the frequencies of CA and SCE. The mitotic index (MI) decreased compared to the control at all concentrations except the lowest one in the 24-h treatment of Carmoisine and the two highest concentrations (150, 300 mu g/mL) in the 48-h treatment. In the 24-h Ponceau 4R treatment, MI decreased compared to the control at all concentrations except the lowest and all concentrations in the 48-h treatment. In contrast, Carmoisine and Ponceau 4R did not affect MN frequency. In the comet test, Carmoisine increased tail length only at the highest concentration, and Ponceau 4R increased tail length at the two highest concentrations. Ponceau 4R also increased tail moment only at the highest concentration. When the results of these four in vitro genotoxicity tests were evaluated together, it was concluded that both food colors were genotoxic, especially at high concentrations, but not at low concentrations.

Cilt

14

Sayı

2

Bağlantı

https://doi.org/10.1093/toxres/tfaf033
https://hdl.handle.net/20.500.12450/5973

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [458]
  • WoS İndeksli Yayınlar Koleksiyonu [2182]



DSpace software copyright © 2002-2015  DuraSpace
İletişim | Geri Bildirim
Theme by 
@mire NV
 

 




| Yönerge | Rehber | İletişim |

DSpace@Amasya

by OpenAIRE
Gelişmiş Arama

sherpa/romeo

Göz at

Tüm DSpaceBölümler & KoleksiyonlarTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreBölüme GöreYayıncıya GöreKategoriye GöreDile GöreErişim ŞekliBu KoleksiyonTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreBölüme GöreYayıncıya GöreKategoriye GöreDile GöreErişim Şekli

Hesabım

GirişKayıt

DSpace software copyright © 2002-2015  DuraSpace
İletişim | Geri Bildirim
Theme by 
@mire NV
 

 


|| Yönerge || Rehber || Kütüphane || Amasya Üniversitesi || OAI-PMH ||

Amasya Üniversitesi Kütüphane ve Dokümantasyon Daire Başkanlığı, Amasya, Turkey
İçerikte herhangi bir hata görürseniz, lütfen bildiriniz: openaccess@amasya.edu.tr

Creative Commons License
DSpace@Amasya by Amasya University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@Amasya: