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Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?

dc.contributor.authorSahin M.
dc.contributor.authorGullu H.
dc.contributor.authorPeker K.
dc.contributor.authorSayar I.
dc.contributor.authorBinici O.
dc.contributor.authorYildiz H.
dc.date.accessioned2019-09-01T12:50:11Z
dc.date.available2019-09-01T12:50:11Z
dc.date.issued2015
dc.identifier.issn1673-5374
dc.identifier.urihttps://dx.doi.org/10.4103/1673-5374.170312
dc.identifier.urihttps://hdl.handle.net/20.500.12450/585
dc.description.abstractThe neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 µg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia. © 2015, Editorial Board of Neural Regeneration Research. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherEditorial Board of Neural Regeneration Researchen_US
dc.relation.isversionof10.4103/1673-5374.170312en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemiaen_US
dc.subjectNerve regenerationen_US
dc.subjectNeural regenerationen_US
dc.subjectNeuroprotectionen_US
dc.subjectParaplegiaen_US
dc.subjectPre-treatmenten_US
dc.subjectPropofolen_US
dc.subjectSpinal corden_US
dc.titleDoes the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?en_US
dc.typearticleen_US
dc.relation.journalNeural Regeneration Researchen_US
dc.identifier.volume10en_US
dc.identifier.issue11en_US
dc.identifier.startpage1825en_US
dc.identifier.endpage1829en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.department-tempSahin, M., Department of Anesthesiology and Reanimation, University of Amasya, Amasya, Turkey -- Gullu, H., Department of Anesthesiology and Reanimation, Mengucek Gazi Research and Training Hospital, Erzincan, Turkey -- Peker, K., Department of General Surgery, University of Erzincan, Erzincan, Turkey -- Sayar, I., Department of Pathology, University of Erzincan, Erzincan, Turkey -- Binici, O., Department of Anesthesiology and Reanimation, Mengucek Gazi Research and Training Hospital, Erzincan, Turkey -- Yildiz, H., Department of Anesthesiology and Reanimation, University of Sutcu Imam, Kahramanmaras, Turkeyen_US


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