ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi

Abstract

ABSTRACT Objective: Age-related macular degeneration (AMD) is the most common cause of advanced visual loss in developed societies. ANXA3 contributes to tumor development by affecting cell signaling pathways, cell profiling, invasion, metastasis and cell apoptosis. The aim of this study was to compare serum ANXA3 levels in wet type and dry type macular degeneration patients with the control group and to investigate whether there is a significant difference between the groups. Material and Methods: A total of 78 patients (39 patients with wet AMD, 39 patients with dry AMD diagnosed at the same time period and 39 healthy controls without any previous diagnosis of macular degeneration) were enrolled in this study. ANXA3 levels were determined by enzyme-linked immunosorbent assay (ELISA). Results: Serum ANXA3 levels were found to be significantly higher in wet AMD than in the control group (p=0.005). In addition, the difference between serum ANXA3 levels of wet and dry AMD patients was found to be significant. It was observed that there was a significant increase in wet type AMD patients (p=0.004). However, no significant difference was found in ANXA3 levels in dry type AMD compared to the control group (p=0.444). Conclusion: These findings suggest that ANXA3 protein may play an important role in age-related macular degeneration.