Monocyte and neutrophil to high density lipoprotein cholesterol ratios are elevated in patients with vitamin D deficiency

Abstract

Aim: It is suggested that Vitamin D deficiency may lead to cardiovascular diseases. Monocyte-High density lipoprotein cholesterol (HDL) ratio (MHR) and Neutrophil-HDL ratio (NHR) are markers which may be used as cardiovascular risk factors, which are associated with inflammation. The purpose of this study is to evaluate the MHR and NHR levels in patients with Vitamin D deficiency. Material and Method: This retrospective study included patients who were tested for Vitamin D levels in our clinic. The subjects were separated into two groups based on their Vitamin D levels and laboratory variables including MHR and NHR were compared. Results: The subjects with serum 25 OH D level lower and higher than 20 ng/ml were compared, and MHR and NHR were detected significantly higher in subjects with Vitamin D deficiency (p:0.003 and p<0.001). Conclusion: Our study indicates for the first time in the literature that MHR and NHR levels increase in Vitamin D deficiency. Our findings suggest that the cardiovascular risk which occurs in Vitamin D deficiency may be associated with the observed increased inflammation. It was detected that MHR and NHR ratios may be used to predict cardiovascular diseases in people with Vitamin D deficiency. Our study also showed that the increased cardiovascular risk which occurs in vitamin D deficiency may be associated with the increased inflammation.