The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia

Abstract

OBJECTIVE: Fibromyalgia (FM) is a clinical syndrome characterized by prom-inent physical and psychological impairment and widespread pain on both sides of the body, above and below the waist, and along the axial skeleton. It often causes sleep difficulties, mem-ory impairment, mood changes, irritable bowel syndrome, and fatigue. Our study aimed to in-vestigate the relationship between FM and pro-lidase (peptidase D) and histone H3 protein levels by comparing a patient group with a healthy control group. PATIENTS AND METHODS: In total, 176 peo-ple were examined in our study, 88 of whom were healthy and 88 of whom had FM. Serum level was measured by ELISA. Then the results were ana-lyzed using SPSS. All p < 0.05 were considered statistically significant.RESULTS: A significant increase in the levels of prolidase was observed in the patient group compared with the control group (6.28-4.68, p <0.001). Histone H3 protein values were not sig-nificantly different between the patient and con-trol groups (p=0.184). The ROC analysis indicat-ed that prolidase was statistically significant in disease prediction (p<0.001, AUC: 0.795 (0.697-0.893), while histone H3 protein was statistically insignificant in predicting disease.CONCLUSIONS: The results of the study show that prolidase activity may play a role in diagnosing FM. In addition, since no study like ours has been performed before, it can bring a new perspective to the literature.