Evaluation of Serum Procalcitonin, Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Pregnancies with Threatened Abortion

Abstract

Objective: The etiology of Threatened Abortion is not clearly known. One of the hypotheses thought to play a role in the pathophysiology of threatened abortion is that bleeding occurring in threatened abortion causes the development of a chronic inflammatory reaction in the decidua. Because of this hypothesis, we aimed to evaluate the relationship between a threatened abortion and inflammatory markers procalcitonin, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR). Methods: This is a prospective, controlled study. Serum procalcitonin, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio of 55 pregnant women diagnosed with threatened abortion were compared with the results of 55 healthy pregnant women. ROC analysis of procalcitonin, NLR and PLR was performed for threatened abortions. Results: Procalcitonin and NLR levels were significantly higher in the threatened abortions group than in the control group (p < 0.05). The area under the curve (AUC) in ROC analysis was within the 95% confidence interval for procalcitonin and NLR, both of which were statistically significant (p < 0.05). Procalcitonin and NLR resulted as appropriate parameters as diagnostic decision-makers in predicting threatened abortions. Conclusion: There is an association between procalcitonin and NLR and threatened abortion. This result may support that inflammatory reaction plays a role in the etiology of threatened abortion.