Evaluation of inflammatory markers in threatened abortions and spontaneous abortions

Abstract

Objectives: To evaluate the relationship between threatened abortion and inflammation markers such as procalcitonin, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio.Material and methods: This was a prospective, controlled study. Serum procalcitonin, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) results of 60 threatened abortions were compared with the results of 60 spontaneous abortions and 60 healthy pregnancies. ROC analyses of procalcitonin, NLR and PLR were performed for threatened abortions. In addition, the threatened abortion group with ongoing pregnancy was divided into two groups according to the presence of hemorrhage area in ultrasonography and re-evaluated in terms of serum procalcitonin levels, NLR and PLR.Results: Procalcitonin and NLR levels were significantly higher in the threatened abortion group than the abortion and control groups (p < 0.05). There was no significant difference between the control and abortion groups. The area under the curve in ROC analysis was within the 95% confidence interval for procalcitonin and NLR and was statistically significant (p < 0.05). Among the abortus imminens, which were divided into two groups according to whether there was hemorrhage area on ultrasonography, procalcitonin, NLR and PLR were higher in patients with bleeding area than without bleeding, but this was not significant (p > 0.05).Conclusions: There is an association between procalcitonin and NLR and threatened abortion. Procalcitonin and NLR may support the diagnosis of threatened abortion.