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dc.contributor.authorTekcan, Akin
dc.contributor.authorYigit, Serbulent
dc.contributor.authorNursal, Ayse F.
dc.contributor.authorTumer, Mehmet K.
dc.contributor.authorYerliyurt, Kaan
dc.contributor.authorKuruca, Nilufer
dc.date.accessioned2024-03-12T19:34:26Z
dc.date.available2024-03-12T19:34:26Z
dc.date.issued2021
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.urihttps://doi.org/10.2174/1871530320666200413092239
dc.identifier.urihttps://hdl.handle.net/20.500.12450/2570
dc.description.abstractBackground/Aims: Recurrent aphthous stomatitis (RAS) is one of the common oral inflammatory diseases. As immunological and genetic factors have been held responsible for the pathogenesis of RAS, the objective of this study was to determine whether the interleukin-1 receptor antagonist (IL-1Ra) gene variable number tandem repeat (VNTR) variant is a risk factor for the development of RAS in Turkish patients and to define its contribution to the increased risk. Methods: The IL-1Ra VNTR variant was evaluated in 169 RAS patients and 171 healthy controls by the polymerase chain reaction (PCR) method. Results: No statistically significant difference was found in the genotype distributions and allele frequencies of IL-1Ra VNTR variant between RAS patients and healthy controls. Conclusion: Lack of association between IL-1Ra VNTR variant and RAS could indicate that IL-1Ra has no significant role in the pathophysiology of RAS. However, it still appears to be very worthwhile to continue to search for cytokine gene variants in order to predict the development of such disease.en_US
dc.language.isoengen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targetsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAphthous stomatitisen_US
dc.subjectproinflammatory cytokinesen_US
dc.subjectInterleukin-1 Receptor Antagonisten_US
dc.subjectpolymerase chain reactionen_US
dc.subjectvariable number tandem repeaten_US
dc.subjectvarianten_US
dc.titleAnalysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitisen_US
dc.typearticleen_US
dc.departmentAmasya Üniversitesien_US
dc.authoridYigit, Serbulent/0000-0002-1019-3964
dc.authoridTumer, Mehmet Kemal/0000-0002-6250-0954
dc.authoridTEKCAN, AKIN/0000-0001-7961-6657
dc.authoridKURUCA, Nilufer/0000-0001-5601-4952
dc.authoridNursal, Ayse Feyda/0000-0001-7639-1122
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.startpage139en_US
dc.identifier.endpage144en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-85101153769en_US
dc.identifier.doi10.2174/1871530320666200413092239
dc.department-temp[Tekcan, Akin] Amasya Univ, Fac Med, Dept Med Biol, Amasya, Turkey; [Yigit, Serbulent] Gaziosmanpasa Univ, Fac Med, Dept Med Biol, Tokat, Turkey; [Yigit, Serbulent] Ondokuz Mayis Univ, Fac Vet Med, Dept Genet, Samsun, Turkey; [Nursal, Ayse F.] Hitit Univ, Fac Med, Dept Med Genet, Corum, Turkey; [Tumer, Mehmet K.] Gaziosmanpasa Univ, Fac Dent, Dept Maxillofacial Surg, Tokat, Turkey; [Yerliyurt, Kaan] Gaziosmanpasa Univ, Fac Dent, Dept Prosthodont, Tokat, Turkey; [Kuruca, Nilufer] Ondokuz Mayis Univ, Fac Vet Med, Dept Pathol, Samsun, Turkeyen_US
dc.identifier.wosWOS:000613440100014en_US
dc.identifier.pmid32282310en_US
dc.authorwosidYigit, Serbulent/ABB-9572-2020
dc.authorwosidTumer, Mehmet Kemal/R-3428-2019
dc.authorwosidNursal, Ayse/ABG-7404-2021


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