• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace Home
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • View Item
  •   DSpace Home
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

The relationship between plasminogen activator Inhibitor-1 levels and the course of disease in COVID-19 patients

xmlui.dri2xhtml.METS-1.0.item-rights

info:eu-repo/semantics/openAccess

Date

2022

Author

Baltan, Ecem
Serin, Erdinc
Avci, Burak Yasin
Akilli, Isil Kibar
Cinar, Ayse Surhan

Metadata

Show full item record

Abstract

Objectives Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system. In our study; we aimed to evaluate serum PAI-1 and other biochemical parameters of COVID-19 patients in terms of disease course and mortality. Methods A total of 40 COVID-19 patients were hospitalized in the service and intensive care unit (ICU) of our hospital from October to December 2020 and 20 healthy volunteers were included in our study. The patients were grouped as those who transferred to the ICU from the service and transferred to service from the ICU. All patients were transferred to the ICU in the following days. The first and second values of the same patients in both the service and the ICU were analyzed by SPSS. Results The PAI-1 levels of the patients in the ICU were significantly higher than the levels of the same patients in the service and the healthy control group (p<0.001). IL-6, ferritin, and D-dimer levels in the ICU of the same patients were significantly higher than the levels of service and healthy control group (p<0.001). A positive correlation was found between initial serum PAI-1 and D-dimer levels in patients hospitalized in the service (p=0.039) and initial serum ferritin and IL-6 levels in the ICU (p=0.031). Conclusions In our study, we found that PAI-1 levels increased significantly with the increase in mortality in COVID-19 patients.

Volume

47

Issue

5

URI

https://doi.org/10.1515/tjb-2022-0044
https://search.trdizin.gov.tr/yayin/detay/1167986
https://hdl.handle.net/20.500.12450/2499

Collections

  • Scopus İndeksli Yayınlar Koleksiyonu [1574]
  • TR-Dizin İndeksli Yayınlar Koleksiyonu [1323]
  • WoS İndeksli Yayınlar Koleksiyonu [2182]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Instruction | Guide | Contact |

DSpace@Amasya

by OpenAIRE
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeDepartmentPublisherCategoryLanguageAccess TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeDepartmentPublisherCategoryLanguageAccess Type

My Account

LoginRegister

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


|| Instruction || Guide || Library || Amasya University || OAI-PMH ||

Amasya Üniversitesi Kütüphane ve Dokümantasyon Daire Başkanlığı, Amasya, Turkey
If you find any errors in content, please contact: openaccess@amasya.edu.tr

Creative Commons License
DSpace@Amasya by Amasya University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@Amasya: