dc.contributor.author | Orhan, Cemal | |
dc.contributor.author | Er, Besir | |
dc.contributor.author | Deeh, Patrick Brice Defo | |
dc.contributor.author | Bilgic, Ahmet Alp | |
dc.contributor.author | Ojalvo, Sara Perez | |
dc.contributor.author | Komorowski, James Richard | |
dc.contributor.author | Sahin, Kazim | |
dc.date.accessioned | 2024-03-12T19:28:56Z | |
dc.date.available | 2024-03-12T19:28:56Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0163-4984 | |
dc.identifier.issn | 1559-0720 | |
dc.identifier.uri | https://doi.org/10.1007/s12011-020-02526-9 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12450/2118 | |
dc.description.abstract | Magnesium (Mg) is an essential mineral required for many physiological processes, including ionic balances in ocular tissues. We compared the effects of different Mg-chelates (Mg oxide, MgO vs. Mg picolinate, MgPic) on retinal function in a high-fat diet (HFD) rats. Forty-two rats were divided into six groups and treated orally for 8 weeks as follows: Control, MgO, MgPic, HFD, HFD + MgO, and HFD + MgPic. Mg was administered at 500 mg of elemental Mg/kg of diet. HFD intake increased the levels of retinal MDA and NF-kappa B, INOS, ICAM, and VEGF but downregulated Nrf2. However, in rats supplemented with MgO and MgPic, the retinal MDA level was decreased, compared with the control and HFD rats. Activities of antioxidant enzymes (SOD, CAT, and GPx) were increased in HFD animals given Mg-chelates (p < 0.001), MgPic being the most effective. Mg supplementation significantly decreased the expression levels of NF-kappa B, INOS, ICAM, and VEGF in HFD rats while increasing the level of Nrf2 (p < 0.001). Mg supplementation significantly decreased the levels of NF-kappa B, INOS, ICAM, and VEGF and increased Nrf2 level in HFD rats (p < 0.001), with stronger effects seen from MgPic. Mg attenuated retinal oxidative stress and neuronal inflammation and could be considered as an effective treatment for ocular diseases. | en_US |
dc.description.sponsorship | Nutrition 21, LLC (Purchase, NY, USA); Turkish Academy of Sciences | en_US |
dc.description.sponsorship | This research was funded by Nutrition 21, LLC (Purchase, NY, USA) and the Turkish Academy of Sciences (in part; KS) | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springernature | en_US |
dc.relation.ispartof | Biological Trace Element Research | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Magnesium oxide | en_US |
dc.subject | Magnesium picolinate | en_US |
dc.subject | Retina | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Inflammation | en_US |
dc.subject | High-fat diet | en_US |
dc.title | Different Sources of Dietary Magnesium Supplementation Reduces Oxidative Stress by Regulation Nrf2 and NF-?B Signaling Pathways in High-Fat Diet Rats | en_US |
dc.type | article | en_US |
dc.department | Amasya Üniversitesi | en_US |
dc.authorid | Orhan, Cemal/0000-0003-4138-7689 | |
dc.authorid | Sahin, Kazim/0000-0001-9542-5244 | |
dc.authorid | Er, Besir/0000-0002-9583-2218 | |
dc.authorid | Komorowski, James R/0000-0003-2399-838X | |
dc.identifier.volume | 199 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | 4162 | en_US |
dc.identifier.endpage | 4170 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopus | 2-s2.0-85098787921 | en_US |
dc.identifier.doi | 10.1007/s12011-020-02526-9 | |
dc.department-temp | [Orhan, Cemal; Sahin, Kazim] Firat Univ, Dept Anim Nutr, Fac Vet Med, TR-23119 Elazig, Turkey; [Er, Besir] Firat Univ, Dept Mol Biol, Fac Sci, Elazig, Turkey; [Deeh, Patrick Brice Defo] Univ Dschang, Dept Anim Biol, Fac Sci, Dschang, Cameroon; [Bilgic, Ahmet Alp] Amasya Univ, Sabuncuoglu Serefeddin Res & Training Hosp, Dept Ophthalmol, Amasya, Turkey; [Ojalvo, Sara Perez; Komorowski, James Richard] Nutr 21 LLC, Res & Dev, Harrison, NY USA | en_US |
dc.identifier.wos | WOS:000605536800004 | en_US |
dc.identifier.pmid | 33409912 | en_US |
dc.authorwosid | Orhan, Cemal/Q-2086-2015 | |
dc.authorwosid | Brice, DEEH DEFO Patrick/AEZ-9023-2022 | |
dc.authorwosid | Sahin, Kazim/D-5625-2009 | |