Yazar "Ayar, Arif" için Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed listeleme
-
Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole Derivatives
Ayar, Arif; Aksahin, Masuk; Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: Pyrrole compounds having a heterocyclic structure are the most researched and biological activities such as antioxidant and anticancer activities. Objective: Herein is a first effort to study the significance ... -
ATP?Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds
Purpose: ABC proteins transport many substrates such as antibiotics and drugs. Increase of ABCs lead chemoresistance in can-cer.In view of this information, in our study, we planned to investigate both PhTAD-substituted ... -
Cytotoxic and Apoptotic Effect ofIris taochia Plant Extracts on Human Breast Cancer (MCF-7) Cells
Yazgan, Burak; Ozcelik, Ozlem; Ayar, Arif; Renda, Gulin; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Introduction: Iris taochia is an endemic plant in Turkey. Iris species has many biological effects such as antibacterial, antiinflammatory, antioxidant and anticancer properties. Apoptosis is a programmed cell death and ... -
Evaluation of maternal and embryotoxic effects following the treatment of chloral hydrate in Drosophila melanogaster
Ayar, Arif; Colak, Deniz Altun; Uysal, Handan (SPRINGER, 2016)Chloral hydrate (CH) is commonly used as a sedative and a hypnotic in pediatric medicine. In this study, the effects of CH on various developmental stages of Drosophila melanogaster were investigated. Different concentrations ... -
Genotoxic and safety assessment of 2 parabens in somatic cells of in vivo Drosophila melanogaster
Ayar, Arif; Uysal, Handan (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2013)The objective of this study was to determine the possible genotoxic effects of the para-hydroxybenzoic acid esters (parabens) of methylparaben, propylparaben, and the mixed paraben groups formed by a combination of these, ... -
Modulatory effects of white tea (Camellia sinensis L. ) on genotoxicity in streptozotocin and cyclophosphamide-treated Drosophila melanogaster
Fidan, Mehmet; Ayar, Arif (Mattioli 1885, 2021)In the present study, it was aimed to determine the antigenotoxic activity of white tea against the genotoxic effect caused by two different alkylating antineoplastic cancer drugs streptozotocin (STZ) and cyclophosphamide ... -
PhTAD-Substituted Dihydropyrrole Compounds Regulate Apoptotic Cell Death in MCF-7 Cells
Breast cancer is the most common type of cancer amongst women. Apoptosis is known as a programmed cell death and this mechanism induces cancer cell death. Dihydropyrrole compounds contain a heterocyclic structure and these ... -
Simultaneous determination of alpha-amyrin and beta-sitosterol in Centranthus longiflorus Stev. Subsp longiflorus Stev and Iris taochia Woronow ex Grossh by GC-MS method
Askin, Hakan; Yilmaz, Bilal; Bakirci, Seyma; Ayar, Arif (MATTIOLI 1885, 2018)Turkey is rich in terms of triterpenes and sterols flora. Triterpenes and sterols hold out for medicinal advances and new drugs. This paper describes a simple, precise, sensitive and specific method for the simultaneous ... -
Survival Rate and Lifespan in Drosophila melanogaster Feeding with White Tea
White tea is a special tea made from the bud and young leaves of some varieties of Camellia sinensis L. Kuntze plant. In this study, it was aimed to determine the effects of white tea on larval mortality in Drosophila ...