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dc.contributor.authorSekeroglu, Vedat
dc.contributor.authorAydin, Birsen
dc.contributor.authorSekeroglu, Zulal Atli
dc.date.accessioned2019-09-01T13:07:06Z
dc.date.available2019-09-01T13:07:06Z
dc.date.issued2011
dc.identifier.issn1513-7368
dc.identifier.urihttps://hdl.handle.net/20.500.12450/1596
dc.descriptionWOS: 000302015800020en_US
dc.descriptionPubMed ID: 22393965en_US
dc.description.abstractPossible protective effects of a methanolic extract of Viscum album (VA) and quercetin (QE) against cyclophosphamide (CP) induced cardiotoxicity, urotoxicity and genotoxicity in mice were evaluated. Mice were administered orally VA (250 mg/kg/day) and QE (50 mg/kg/day) for 10 days alone or in combination with CP. After the same doses of VA and QE given for 7 days, rats were intraperitoneally administered CP (40 mg/kg) on days 8 and 9 of the experiment. Cardiotoxic, urotoxic and genotoxic effects were examined in serum, heart, bladder and bone marrow. Significant decreases in the levels of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase), glutathione-S-transferases, reduced glutathione and mitotic index were observed. QE completely and VA partly ameliorated almost of all the examined parameters when given together with CP. Higher total nitrate/nitrite levels were observed in the myocardial tissue treated with QE and VA in combination with CP. In addition, the pre-treatment with VA and QE together with CP significantly decreased chromosome aberrations and aberrant cells compared to CP alone. Results from the current study suggest that QE and VA supplementation attenuates CP induced cardiotoxicity, urotoxicity and genotoxicity through a mechanism related to their ability to decrease oxidative stress and inflammation, and at least in part to its protective effects on the cardiovascular system. In addition, VA and QE may play a role in reducing cytogenotoxicity induced by anti-neoplastic drugs during cancer chemotherapy.en_US
dc.language.isoengen_US
dc.publisherASIAN PACIFIC ORGANIZATION CANCER PREVENTIONen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectViscum albumen_US
dc.subjectquercetinen_US
dc.subjectcyclophosphamideen_US
dc.subjectoxidative stressen_US
dc.subjectchromosomal aberrationsen_US
dc.titleViscum album L. Extract and Quercetin Reduce Cyclophosphamide-Induced Cardiotoxicity, Urotoxicity and Genotoxicity in Miceen_US
dc.typearticleen_US
dc.relation.journalASIAN PACIFIC JOURNAL OF CANCER PREVENTIONen_US
dc.authoridSEKEROGLU, Vedat -- 0000-0002-8547-6571; Atli Sekeroglu, Zulal -- 0000-0002-3552-3819en_US
dc.identifier.volume12en_US
dc.identifier.issue11en_US
dc.identifier.startpage2925en_US
dc.identifier.endpage2931en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.department-temp[Sekeroglu, Vedat -- Sekeroglu, Zulal Atli] Ordu Univ, Fac Sci, Dept Biol, Ordu, Turkey -- [Aydin, Birsen] Amasya Univ, Fac Sci, Dept Biol, Amasya, Turkeyen_US


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