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dc.contributor.authorAydin, Birsen
dc.contributor.authorUnsal, Meftun
dc.contributor.authorSekeroglu, Zulal A.
dc.contributor.authorGulbahar, Yavuz
dc.date.accessioned2019-09-01T13:07:01Z
dc.date.available2019-09-01T13:07:01Z
dc.date.issued2011
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.urihttps://dx.doi.org/10.1007/s12011-010-8781-3
dc.identifier.urihttps://hdl.handle.net/20.500.12450/1580
dc.descriptionWOS: 000293706900036en_US
dc.descriptionPubMed ID: 20676799en_US
dc.description.abstractOxidative stress and inflammation are implicated in the pathogenesis of cisplatin-induced toxicity. PycnogenolA (R) is known for its strong antioxidant and anti-inflammatory effects. In this study, the possible protective effects of pycnogenol on kidney, bone marrow, and red blood cells in rats treated with cisplatin were investigated. The rats were divided into four groups. Group 1 was the control and groups 2, 3, and 4 were orally treated with pycnogenol (200 mg/kg bw, o.p) for 5 days, treated with cisplatin (7 mg/kg bw, i.p.) on the fifth day and treated with cisplatin plus pycnogenol, respectively. Antioxidative parameters in kidney and red blood cells were measured. Chromosome anomalies in bone marrow and renal histopathology were also investigated. Activities of pro-oxidant enzymes (myeloperoxidase and xanthine oxidase), malondialdehyde, and nitric oxide levels significantly increased but antioxidant enzymes activities decreased in the kidneys and red blood cells after cisplatin treatment. Pycnogenol treatment prior to the administration of cisplatin significantly decreased cisplatin-induced injury, as evidenced by its normalizing these parameters. Chromosomal aberrations decreased and mitotic index frequencies increased in bone marrow treated with cisplatin plus pycnogenol. These findings suggest that pycnogenol may be a useful protective agent against the toxicity associated with cisplatin therapy.en_US
dc.language.isoengen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.isversionof10.1007/s12011-010-8781-3en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectPycnogenol (R)en_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidant enzymesen_US
dc.subjectChromosomal aberrationsen_US
dc.titleThe Antioxidant and Antigenotoxic Effects of Pycnogenol (R) on Rats Treated With Cisplatinen_US
dc.typearticleen_US
dc.relation.journalBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.authoridAtli Sekeroglu, Zulal -- 0000-0002-3552-3819; GULBAHAR, MUSTAFA YAVUZ -- 0000-0001-8268-7659en_US
dc.identifier.volume142en_US
dc.identifier.issue3en_US
dc.identifier.startpage638en_US
dc.identifier.endpage650en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.department-temp[Aydin, Birsen] Amasya Univ, Dept Biol, Fac Sci, TR-05100 Amasya, Turkey -- [Unsal, Meftun] Ondokuz Mayis Univ, Dept Chest, Fac Med, TR-55139 Kurupelit, Samsun, Turkey -- [Sekeroglu, Zulal A.] Ordu Univ, Dept Biol, Fac Arts & Sci, TR-52750 Persembe, Ordu, Turkey -- [Gulbahar, Yavuz] Ondokuz Mayis Univ, Dept Pathol, Fac Vet, TR-55139 Kurupelit, Samsun, Turkeyen_US


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