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dc.contributor.authorAyar, Arif
dc.contributor.authorUysal, Handan
dc.date.accessioned2019-09-01T13:06:40Z
dc.date.available2019-09-01T13:06:40Z
dc.date.issued2013
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.urihttps://dx.doi.org/10.3906/biy-1303-60
dc.identifier.urihttps://hdl.handle.net/20.500.12450/1521
dc.descriptionWOS: 000325747400007en_US
dc.description.abstractThe objective of this study was to determine the possible genotoxic effects of the para-hydroxybenzoic acid esters (parabens) of methylparaben, propylparaben, and the mixed paraben groups formed by a combination of these, which are used as preservative substances in the food, cosmetic, and drug industries, on Drosophila melanogaster using the wing somatic mutation and recombination test (SMART). According to the data obtained from microscopic analysis, no increase was determined in the single type clone number at various concentrations (100, 150, 200, and 250 mM) of paraben groups in comparison with the control group. In addition, increases corresponding to the concentration increase in the single type and twin clone numbers were observed in the mixed paraben application group in comparison to the control group. However, this increase was not determined to create a statistically significant difference (P > 0.05). As a result of the data that we obtained, it has been concluded that parabens show toxic effects but no genotoxic effects on D. melanogaster.en_US
dc.description.sponsorshipAtaturk University Research Foundation [2010/45]; Ataturk Universityen_US
dc.description.sponsorshipThis study was supported by the Ataturk University Research Foundation (Project Code: 2010/45). The authors would like to thank Ataturk University for financial support for the project.en_US
dc.language.isoengen_US
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEYen_US
dc.relation.isversionof10.3906/biy-1303-60en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectgenotoxicityen_US
dc.subjectmethylparabenen_US
dc.subjectpropylparabenen_US
dc.subjectsomatic mutationen_US
dc.subjectwing spot testen_US
dc.titleGenotoxic and safety assessment of 2 parabens in somatic cells of in vivo Drosophila melanogasteren_US
dc.typearticleen_US
dc.relation.journalTURKISH JOURNAL OF BIOLOGYen_US
dc.identifier.volume37en_US
dc.identifier.issue6en_US
dc.identifier.startpage683en_US
dc.identifier.endpage688en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.department-temp[Ayar, Arif] Amasya Univ, Sabuncuoglu Serefeddin Vocat Sch Hlth Serv, Amasya, Turkey -- [Uysal, Handan] Ataturk Univ, Fac Sci, Dept Biol, Erzurum, Turkeyen_US


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