Electrochemistry of cefditoren pivoxil and its voltammetric determination

Abstract

Electrochemical behavior of cefditoren pivoxil (CTP) was studied via experimental electrochemical methods and theoretical calculations performed at B3LYP/6-31 + G(d)//AM1 level. Experimental studies were carried out based on an irreversible 4e-/4H+ reduction peak at ca. -0.8 V on hanging mercury drop electrode (HMDE) and irreversible 1e-/1H+ oxidation of CTP at ca. 0.8 V on glassy carbon electrode (GCE) versus Ag/AgCl, KCl (3.0 M) in Britton-Robinson buffer at pH 6.0 and 4.0, respectively. Tentative reduction and oxidation mechanisms were proposed based on computational and experimental results. Square-wave adsorptive stripping voltammetric methods have been developed and validated for quantification of CTP in different samples. Linear working range was established as 0.15-15.0 mu M for HMDE and 1.0-50.0 mu M for GCE. Limit of quantification (S/N = 10) was calculated to be (0.10 +/- 0.02) mu M and (0.80 +/- 0.03) mu M for HMDE and GCE, respectively. Methods were successfully applied to assay the drug in tablets and human serum with good recoveries between (99.2 +/-. 11.6) % and (102.5 +/- 9.5) % having relative standard deviation less than 10%. (C) 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.