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dc.contributor.authorCelik, Ahmet
dc.contributor.authorIzci, Servet
dc.contributor.authorKobat, Mehmet Ali
dc.contributor.authorAtes, Ahmet Hakan
dc.contributor.authorCakmak, Abdulkadir
dc.contributor.authorCakilli, Yasin
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorZoghi, Mehdi
dc.date.accessioned2019-09-01T13:05:06Z
dc.date.available2019-09-01T13:05:06Z
dc.date.issued2016
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.urihttps://dx.doi.org/10.5152/AnatolJCardiol.2015.6474
dc.identifier.urihttps://hdl.handle.net/20.500.12450/1179
dc.descriptionWOS: 000384427500009en_US
dc.descriptionPubMed ID: 27004711en_US
dc.description.abstractObjective: The awareness, time in therapeutic range (TTR), and safety of warfarin therapy were investigated in the adult Turkish population. Methods: This multicenter prospective study includes 4987 patients using warfarin and involved regular international normalized ratio (INR) monitoring between January 1, 2014 and December 31, 2014. TTR was calculated according to F.R. Roosendaal's algorithm. Awareness was evaluated based on the patients' knowledge of warfarin's affect and food-drug interactions. esults: The mean TTR of patients was 49.52 +/- 22.93%. The patients with hypertension (55.3%), coronary artery disease (23.2%), congestive heart failure (24.5%), or smoking habit (20.8%) had significantly lower TTR levels than the others. Of the total number of patients, 42.6% had a mechanical valve, 38.4% had non-valvular atrial fibrillation (AF), and 19% had other indications for warfarin. Patients with other indications had lower TTR levels than those with mechanical valve and non-valvular AF (p=0.018). Warfarin awareness decreased in higher age groups. The knowledge of warfarin's food-drug interactions was 55%. People with higher warfarin awareness had higher TTR levels. Patients with <= 8 INR monitoring/year had lower TTR levels (46.4 +/- 25.3 vs. 51.1 +/- 21.3, respectively, p<0.001) and lower awareness (44.6% vs. 60.6%, p<0.001) than patients with >= 8 INR monitoring/year. In this study, 20.1% of the patients had a bleeding event (major bleeding 15.8%, minor bleeding 84.2%) within a year. Conclusion: Both the mean TTR ratios and awareness of the Turkish population on warfarin therapy were found to be low. It was thought that low TTR levels of the Turkish population may be caused by the low awareness of warfarin, warfarin's food-drug interactions, and high rates of concomitant diseases.en_US
dc.language.isoengen_US
dc.publisherTURKISH SOC CARDIOLOGYen_US
dc.relation.isversionof10.5152/AnatolJCardiol.2015.6474en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttime in therapeutic rangeen_US
dc.subjectwarfarinen_US
dc.subjectTurkish populationen_US
dc.titleThe awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: WARFARIN-TRen_US
dc.typearticleen_US
dc.relation.journalANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.authoridCelikcan, Havva Didem -- 0000-0003-4868-861X; Altay, Servet -- 0000-0001-7112-3970; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628; YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; Ozbek, Kerem -- 0000-0002-0603-3976; Kis, Mehmet -- 0000-0003-0775-8992; Koksal Cakirlar, Fatma -- 0000-0003-4279-434Xen_US
dc.identifier.volume16en_US
dc.identifier.issue8en_US
dc.identifier.startpage595en_US
dc.identifier.endpage600en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.department-temp[Celik, Ahmet] Mersin Univ, Fac Med, Dept Cardiol, Mersin, Turkey -- [Izci, Servet] Kosuyolu Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Kobat, Mehmet Ali] Firat Univ, Fac Med, Dept Cardiol, Elazig, Turkey -- [Ates, Ahmet Hakan] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Cakmak, Abdulkadir] Amasya Univ, Fac Med, Dept Cardiol, Amasya, Turkey -- [Cakilli, Yasin] Siyami Ersek Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- [Zoghi, Mehdi] Ege Univ, Dept Cardiol, Fac Med, Izmir, Turkeyen_US


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