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alpha-Amination and the 5-exo-trig cyclization reaction of sulfur-containing Schiff bases with N-phenyltriazolinedione and their anti-lipid peroxidation activity

dc.contributor.authorPelit, Emel
dc.contributor.authorOikonomou, Kosmas
dc.contributor.authorGul, Melek
dc.contributor.authorGeorgiou, Dimitra
dc.contributor.authorSzafert, Slawomir
dc.contributor.authorKatsamakas, Sotirios
dc.contributor.authorHadjipavlou-Litina, Dimitra
dc.contributor.authorElemes, Yiannis
dc.date.accessioned2019-09-01T13:04:43Z
dc.date.available2019-09-01T13:04:43Z
dc.date.issued2017
dc.identifier.issn1631-0748
dc.identifier.issn1878-1543
dc.identifier.urihttps://dx.doi.org/10.1016/j.crci.2016.05.024
dc.identifier.urihttps://hdl.handle.net/20.500.12450/1060
dc.descriptionWOS: 000400656200012en_US
dc.description.abstractTriazolinedione quenches efficiently the 1,2-dipoles from Schiff bases of glycine esters which are formed via a [1,2-H]-prototropic shift of their alpha-hydrogens, and affords the respective alpha-aminated products in good yields. Competition experiments show a stabilization of the 1,2-dipole from the sulfide substituent. 5-exo-trig cyclization of N-PhTAD with Schiff bases of other amino acids gave triazolines. The antioxidative and lipoxygenase inhibitory activities of the novel synthesized compounds were studied. (C) 2016 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.relation.isversionof10.1016/j.crci.2016.05.024en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTriazolinedioneen_US
dc.subjectAmino aciden_US
dc.subjectSchiff baseen_US
dc.subject1,2-Dipoleen_US
dc.subjectalpha-Aminationen_US
dc.subject5-exo-trig cyclizationen_US
dc.titlealpha-Amination and the 5-exo-trig cyclization reaction of sulfur-containing Schiff bases with N-phenyltriazolinedione and their anti-lipid peroxidation activityen_US
dc.typearticleen_US
dc.relation.journalCOMPTES RENDUS CHIMIEen_US
dc.authoridKatsamakas, Sotirios -- 0000-0001-8715-0359; Pelit, Emel -- 0000-0002-5717-7355; Gul, Melek -- 0000-0002-0037-1202en_US
dc.identifier.volume20en_US
dc.identifier.issue4en_US
dc.identifier.startpage424en_US
dc.identifier.endpage434en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.department-temp[Pelit, Emel] Kirklareli Univ, Fac Arts & Sci, Dept Chem, Kirklareli, Turkey -- [Oikonomou, Kosmas -- Georgiou, Dimitra -- Elemes, Yiannis] Univ Ioannina, Dept Chem, GR-45110 Ioannina, Greece -- [Gul, Melek] Amasya Univ, Fac Arts & Sci, Dept Chem, Amasya, Turkey -- [Szafert, Slawomir] Univ Wroclaw, Dept Chem, 14 F Joliot Curie, PL-50383 Wroclaw, Poland -- [Katsamakas, Sotirios -- Hadjipavlou-Litina, Dimitra] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Fac Hlth Sci, Thessaloniki 54124, Greeceen_US


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