Yazar "Yildirim, Tuba" için listeleme
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2-Hydroxyanthraquinone substituted cyclotriphosphazenes: Synthesis and cytotoxic activities in cancer cell lines
Ciftci, Gonul Yenilmez; Demir, Gizem; Senkuytu, Elif; Ecik, Esra Tanriverdi; Aksahin, Masuk; Yildirim, Tuba (Elsevier Science Sa, 2021)Scientists continue to synthesize substances that have cytotoxic effects and examine their properties to overcome cancer for a long time. This study is aimed at preparing novel cyclotriphosphazene derivatives and examining ... -
Antioxidant and Cytotoxic Activity Studies of Sulfur Containing Glycine Imine Derivatives MCF-7 and DLD-1 Cell Lines
Mesci, Seda; Gul, Melek; Yildirim, Tuba (Marmara Univ, Inst Health Sciences, 2021)Objective: To investigate the antioxidant and cytotoxic activities of sulfur-containing glycine imine derivatives MCF-7 (human breast adenocarcinoma) and DLD-1 (colorectal adenocarcinoma) cell lines. Methods: This study ... -
Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole Derivatives
Ayar, Arif; Aksahin, Masuk; Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: Pyrrole compounds having a heterocyclic structure are the most researched and biological activities such as antioxidant and anticancer activities. Objective: Herein is a first effort to study the significance ... -
The bioactive new type paraben decorated dispiro-cyclotriphosphaze compounds: synthesis, characterization and cytotoxic activity studies
Senkuytu, Elif; Akbas, Nadide; Yildirim, Tuba; Ciftci, Gonul Yenilmez (Elsevier, 2022)Cancer is a leading cause of death worldwide and hence studies to find anti-cancer agents for its treatment continue to grow in importance. Generally, cytotoxic drugs have been used for cancer treatment in susceptible ... -
Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes
Yildirim, Tuba; Senkuytu, Elif; Ergene, Emel; Bilgin, Kemal; Uludag, Yildiz; Ciftci, Gonul Yenilmez (WILEY-V C H VERLAG GMBH, 2018)In this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass ... -
Comparison of biofilm formation and efflux pumps in ESBL and carbapenemase producing Klebsiella pneumoniae
Yazgan, Burak; Turkel, Ibrahim; Guckan, Ridvan; Kilinc, Cetin; Yildirim, Tuba (J INFECTION DEVELOPING COUNTRIES, 2018)Introduction: Klebsiella pneumoniae is an opportunistic pathogen that causes a range of diseases. The appearance of extended-spectrum beta-lactamase-and carbapenemase-producing strains, in addition to the biofilm-forming ... -
Cyclotriphosphazenes: Pre-harvest foliar applications improve antioxidant activity by increasing phenolic compounds in Lavandula angustifolia Mill.
Acikgoz, Muhammed Akif; Tuluce, Nagihan Bayik; Kocaman, Beril; Ay, Ebru Bati; Yildirim, Tuba; Ciftci, Yenilmez (Elsevier, 2024)The versatile chemical structures of cyclotriphosphazenes (CTPs) and their derivatives make them useful for various applications, including serving as plant nutrients to enhance the production of bioactive compounds. ... -
Cytotoxic and Apoptotic Effect ofIris taochia Plant Extracts on Human Breast Cancer (MCF-7) Cells
Yazgan, Burak; Ozcelik, Ozlem; Ayar, Arif; Renda, Gulin; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Introduction: Iris taochia is an endemic plant in Turkey. Iris species has many biological effects such as antibacterial, antiinflammatory, antioxidant and anticancer properties. Apoptosis is a programmed cell death and ... -
Determination of biofilm formation, antibiotic susceptibility profiles and quorum sensing mediated virulence factors in ceftazidime resistant Pseudomonas aeruginosa
Baskan, Ceren; Yildirim, Tuba; Bilgin, Melek; Sivas, Hulya (Springer, 2023)This study aims to investigate the relationship between the antibiotic resistance, biofilm production, virulence factors, and quorum sensing systems of Pseudomonas aeruginosa. First, disc diffusion and microdilution tests ... -
Determination of PER-1 and OXA-10-like beta-lactamases in Ceftazidime-Resistant Pseudomonas aeruginosa Isolates by Molecular Methods
Sogut, Mehtap Unlu; Yildirim, Tuba; Birinci, Asuman; Durupinar, Belma (ORTADOGU AD PRES & PUBL CO, 2011)Objective: Pseudomonas aeruginosa is one of the important nosocomial pathogens and resistant to many antibiotics including beta-lactams. PER-1 and OXA-10 type extended-spectrum beta-lactamases (ESBLs), the major beta-lactamases, ... -
DNA interaction analysis of fluorenylidene double bridged cyclotriphosphazene derivatives
Senkuytu, Elif; Yildirim, Tuba; Olcer, Zehra; Uludag, Yildiz; Ciftci, Gonul Yenilmez (ELSEVIER SCIENCE SA, 2018)DNA is a target molecule for anticancer drug development, and investigation on DNA interactions with synthesized potential drugs has great importance in order to discover new drug candidates, hence in this study an ... -
Downregulation of HSP27 by isoindole-derived pyrrolidines suppressing multidrug resistance (MDR) and inducing apoptosis in MCF-7 and DLD-1 cell lines
Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Natl Inst Science Communication-Niscair, 2024)In most cancer treatments, major problem arises from the prevention of cell death (apoptosis suppression) with the development of drug resistance. Anticancer agents that ensure elimination of drug resistance and drug-resistant ... -
Effects of some flavor enhancer food additives on expression of cancer-related genes in MCF-7 and MCF-12A cells
Bolukbasi, Ekrem; Avuloglu-Yilmaz, Ece; Yildirim, Tuba (Taylor & Francis As, 2023)Food additives change the appearance and taste of foods, prevent their deterioration and keep them longer; are very important chemical compounds in terms of food technology. In this study, the cytotoxicity of the monosodium ... -
Examination of Triazolinedione-Derived Dihydropyrrole Hybrid Compounds: ER Stress-Related Apoptosis in Breast Cancer Cells, Molecular Docking, and ADMET Analysis
Mesci, Seda; Ayar, Arif; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2024)Background In many types of cancer, uncontrolled growth and proliferation of cells occur due to abnormalities in their genes, mutations of pro-apoptotic proteins, or upregulation of anti-apoptotic proteins. Triazolinedione ... -
Explorations of ATP-Binding Cassette Transporters and Apoptosis Signal Pathways of 2-Hydroxyanthraquinone Substituted Cyclotriphosphazenes in MCF-7 and DLD-1 Cell Lines
Yazgan, Burak; Mesci, Seda; Bayik, Nagihan; Aksahin, Masuk; Ciftci, Gonul Yenilmez; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: As a class with biological properties, such as anti-cancer, anti-bacterial, anti-HIV, and various physical effects, phosphazene derivatives constitute the most striking part of inorganic compounds. Anthraquinones, ... -
First paraben substituted cyclotetraphosphazene compounds and DNA interaction analysis with a new automated biosensor
Ciftci, Gonul Yenilmez; Senkuytu, Elif; Incir, Saadet Elif; Yuksel, Fatma; Olcer, Zehra; Yildirim, Tuba; Kilic, Adem; Uludag, Yildiz (ELSEVIER ADVANCED TECHNOLOGY, 2016)Cancer, as one of the leading causes of death in the world, is caused by malignant cell division and growth that depends on rapid DNA replication. To develop anti-cancer drugs this feature of cancer could be exploited by ... -
The first synthesis and characterization of spiro and ansa-cyclotriphosphazenes with 3-Hydroxyflavone and induction of apoptosis in breast cancer (MCF-7)
Ciftci, Gonul Yenilmez; Koksal, Burak; Kitmur, Ibrahim; Mesci, Seda; Ay, Ebru Bati; Yildirim, Tuba (Elsevier, 2024)In this study, the first series of 3-Hydroxyflavone substituted spiro, ansa-1,3-propanedioxy and 2,2-dimethyl 1,3propanedioxy substituted cyclotriphosphazene compounds 912 were synthesized and their structures were ... -
Generation of Mouse Hybridomas Secreting Anti-Salmonella Enteritidis Antibodies and Their Preliminary Characterization
Buyuktanir, Ozlem; Yagci, Tamer; Findik, Arzu; Yildirim, Tuba; Yurdusev, Nevzat (KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2011)BALB/c mice were intraperitoneally immunized with inactivated bacteria for generation of monoclonal anti-S. Enteritidis antibody. The spleen cells of the highest responder animal at fifth immunization were used as the ... -
Genotoxic and Antigenotoxic Effects of Some Plant Species of Lamiaceae Family
Kilic, Dudu Duygu; Ayar, Arif; Baskan, Ceren; Yildirim, Tuba (Osman SAĞDIÇ, 2018)Lamiaceae family is one of the members of important plants, using as a agents for alternative medicine treatments. Our aim was to investigate both antigenotoxic and genotoxic effects three different plants species belonging ... -
In Vitro Effects of Ivermectin and Sulphadiazine on Toxoplasma gondii
Bilgin, Melek; Yildirim, Tuba; Hokelek, Murat (AVES YAYINCILIK, 2013)Objective: Ivermectin and sulphadiazine were tested individually to determine their in vitro effects on Toxoplasma gondii grown in human epidermoid larynx carcinoma (Hep-2) cell culture. Study Design: In-vitro study. ...
