Yazar "Yildirim, Tuba" için listeleme
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2-Hydroxyanthraquinone substituted cyclotriphosphazenes: Synthesis and cytotoxic activities in cancer cell lines
Ciftci, Gonul Yenilmez; Demir, Gizem; Senkuytu, Elif; Ecik, Esra Tanriverdi; Aksahin, Masuk; Yildirim, Tuba (Elsevier Science Sa, 2021)Scientists continue to synthesize substances that have cytotoxic effects and examine their properties to overcome cancer for a long time. This study is aimed at preparing novel cyclotriphosphazene derivatives and examining ... -
Antioxidant and Cytotoxic Activity Studies of Sulfur Containing Glycine Imine Derivatives MCF-7 and DLD-1 Cell Lines
Mesci, Seda; Gul, Melek; Yildirim, Tuba (Marmara Univ, Inst Health Sciences, 2021)Objective: To investigate the antioxidant and cytotoxic activities of sulfur-containing glycine imine derivatives MCF-7 (human breast adenocarcinoma) and DLD-1 (colorectal adenocarcinoma) cell lines. Methods: This study ... -
Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole Derivatives
Ayar, Arif; Aksahin, Masuk; Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: Pyrrole compounds having a heterocyclic structure are the most researched and biological activities such as antioxidant and anticancer activities. Objective: Herein is a first effort to study the significance ... -
The bioactive new type paraben decorated dispiro-cyclotriphosphaze compounds: synthesis, characterization and cytotoxic activity studies
Senkuytu, Elif; Akbas, Nadide; Yildirim, Tuba; Ciftci, Gonul Yenilmez (Elsevier, 2022)Cancer is a leading cause of death worldwide and hence studies to find anti-cancer agents for its treatment continue to grow in importance. Generally, cytotoxic drugs have been used for cancer treatment in susceptible ... -
Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes
Yildirim, Tuba; Senkuytu, Elif; Ergene, Emel; Bilgin, Kemal; Uludag, Yildiz; Ciftci, Gonul Yenilmez (WILEY-V C H VERLAG GMBH, 2018)In this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass ... -
Comparison of biofilm formation and efflux pumps in ESBL and carbapenemase producing Klebsiella pneumoniae
Yazgan, Burak; Turkel, Ibrahim; Guckan, Ridvan; Kilinc, Cetin; Yildirim, Tuba (J INFECTION DEVELOPING COUNTRIES, 2018)Introduction: Klebsiella pneumoniae is an opportunistic pathogen that causes a range of diseases. The appearance of extended-spectrum beta-lactamase-and carbapenemase-producing strains, in addition to the biofilm-forming ... -
Cytotoxic and Apoptotic Effect ofIris taochia Plant Extracts on Human Breast Cancer (MCF-7) Cells
Yazgan, Burak; Ozcelik, Ozlem; Ayar, Arif; Renda, Gulin; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Introduction: Iris taochia is an endemic plant in Turkey. Iris species has many biological effects such as antibacterial, antiinflammatory, antioxidant and anticancer properties. Apoptosis is a programmed cell death and ... -
Determination of biofilm formation, antibiotic susceptibility profiles and quorum sensing mediated virulence factors in ceftazidime resistant Pseudomonas aeruginosa
Baskan, Ceren; Yildirim, Tuba; Bilgin, Melek; Sivas, Hulya (Springer, 2023)This study aims to investigate the relationship between the antibiotic resistance, biofilm production, virulence factors, and quorum sensing systems of Pseudomonas aeruginosa. First, disc diffusion and microdilution tests ... -
Determination of PER-1 and OXA-10-like beta-lactamases in Ceftazidime-Resistant Pseudomonas aeruginosa Isolates by Molecular Methods
Sogut, Mehtap Unlu; Yildirim, Tuba; Birinci, Asuman; Durupinar, Belma (ORTADOGU AD PRES & PUBL CO, 2011)Objective: Pseudomonas aeruginosa is one of the important nosocomial pathogens and resistant to many antibiotics including beta-lactams. PER-1 and OXA-10 type extended-spectrum beta-lactamases (ESBLs), the major beta-lactamases, ... -
DNA interaction analysis of fluorenylidene double bridged cyclotriphosphazene derivatives
Senkuytu, Elif; Yildirim, Tuba; Olcer, Zehra; Uludag, Yildiz; Ciftci, Gonul Yenilmez (ELSEVIER SCIENCE SA, 2018)DNA is a target molecule for anticancer drug development, and investigation on DNA interactions with synthesized potential drugs has great importance in order to discover new drug candidates, hence in this study an ... -
Effects of some flavor enhancer food additives on expression of cancer-related genes in MCF-7 and MCF-12A cells
Bolukbasi, Ekrem; Avuloglu-Yilmaz, Ece; Yildirim, Tuba (Taylor & Francis As, 2023)Food additives change the appearance and taste of foods, prevent their deterioration and keep them longer; are very important chemical compounds in terms of food technology. In this study, the cytotoxicity of the monosodium ... -
Explorations of ATP-Binding Cassette Transporters and Apoptosis Signal Pathways of 2-Hydroxyanthraquinone Substituted Cyclotriphosphazenes in MCF-7 and DLD-1 Cell Lines
Yazgan, Burak; Mesci, Seda; Bayik, Nagihan; Aksahin, Masuk; Ciftci, Gonul Yenilmez; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: As a class with biological properties, such as anti-cancer, anti-bacterial, anti-HIV, and various physical effects, phosphazene derivatives constitute the most striking part of inorganic compounds. Anthraquinones, ... -
First paraben substituted cyclotetraphosphazene compounds and DNA interaction analysis with a new automated biosensor
Ciftci, Gonul Yenilmez; Senkuytu, Elif; Incir, Saadet Elif; Yuksel, Fatma; Olcer, Zehra; Yildirim, Tuba; Kilic, Adem; Uludag, Yildiz (ELSEVIER ADVANCED TECHNOLOGY, 2016)Cancer, as one of the leading causes of death in the world, is caused by malignant cell division and growth that depends on rapid DNA replication. To develop anti-cancer drugs this feature of cancer could be exploited by ... -
Generation of Mouse Hybridomas Secreting Anti-Salmonella Enteritidis Antibodies and Their Preliminary Characterization
Buyuktanir, Ozlem; Yagci, Tamer; Findik, Arzu; Yildirim, Tuba; Yurdusev, Nevzat (KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2011)BALB/c mice were intraperitoneally immunized with inactivated bacteria for generation of monoclonal anti-S. Enteritidis antibody. The spleen cells of the highest responder animal at fifth immunization were used as the ... -
In Vitro Effects of Ivermectin and Sulphadiazine on Toxoplasma gondii
Bilgin, Melek; Yildirim, Tuba; Hokelek, Murat (AVES YAYINCILIK, 2013)Objective: Ivermectin and sulphadiazine were tested individually to determine their in vitro effects on Toxoplasma gondii grown in human epidermoid larynx carcinoma (Hep-2) cell culture. Study Design: In-vitro study. ... -
Investigation of Panton-Valentine Leukocidin Presence in the Clinical Strains of Staphylococcus aureus
Cirit, Osman Sezer; Yildirim, Tuba; Coban, Ahmet Yilmaz (AVES YAYINCILIK, 2011)Objective: In this study, the presence of Panton-Valentine Leukocidin (PVL) was investigated in the Staphylococcus aureus clinical isolates by PCR. Material and Methods: In this study, 130 MRSA and 20 methicillin-susceptible ... -
Investigation of Plasmid-Mediated Quinolone Resistance in Pseudomonas aeruginosa Strains Isolated from Cystic Fibrosis Patients
Coban, Ahmet Yilmaz; Cayci, Yeliz Tanriverdi; Yildirim, Tuba; Erturan, Zayre; Durupinar, Belma; Bozdogan, Bulent (ANKARA MICROBIOLOGY SOC, 2011)Pseudomonas aeruginosa which is widely found in the environment, may lead to serious nosocomial infections. Due to its intrinsic resistance to many antibacterial agents, treatment of P.aeruginosa infections usually present ... -
Investigation of the relationship between class-1 integrons and per-1 enzyme in ceftazidime resistant Pseudomonas aeruginosa
Opus, Aysegul; Yildirim, Tuba; Birinci, Asuman; Durupinar, Belma (SCIENTIFIC PUBLISHERS INDIA, 2017)Pseudomonas aeruginosa strains, especially multidrug resistant, have great of importance among nosocomial infection isolates. Production of beta lactamase is an important mechanism in gram-negative bacteria for resistance ... -
Molecular characterization of extended-spectrum ?-lactamases-producing Enterobacteriaceae species in ground beef and chicken meat
Inat, Gokhan; Siriken, Belgin; Ciftci, Alper; Erol, Irfan; Baskan, Ceren; Yildirim, Tuba (Elsevier, 2023)The objectives of this study were i) to characterize extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) using pheno- and genotyping methods, ii) to evaluate the antimicrobial resistance pattern against ... -
Overexpression of peptide deformylase in breast, colon, and lung cancers
Randhawa, Harsharan; Chikara, Shireen; Gehring, Drew; Yildirim, Tuba; Menon, Jyotsana; Reindl, Katie M. (BIOMED CENTRAL LTD, 2013)Background: Human mitochondrial peptide deformylase (PDF) has been proposed as a novel cancer therapeutic target. However, very little is known about its expression and regulation in human tissues. The purpose of this study ...
