Yazar "Yazgan, Burak" için listeleme
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Acute treadmill exercise induces mitochondrial unfolded protein response in skeletal muscle of male rats
Turkel, Ibrahim; Kubat, Gokhan Burcin; Fatsa, Tugba; Acet, Ozgu; Ozerklig, Berkay; Yazgan, Burak; Simsek, Gulcin (Elsevier, 2025)Mitochondria are often referred to as the energy centers of the cell and are recognized as key players in signal transduction, sensing, and responding to internal and external stimuli. Under stress conditions, the mitochondrial ... -
Adeninin indüklediği kronik böbrek yetmezliğinde adropin ve speksinin inflamatuvar yolaklara etkisinin belirlenmesi
Avcı, Filiz (Amasya Üniversitesi, 2021)Kronik böbrek yetmezliği (KBY), glomerüler filtrasyon hızındaki (GFH) azalmanın bir sonucu olarak böbrek fonksiyonlarında kronik ve ilerleyici bir bozulma olarak tanımlanmaktadır. KBY kronik inflamatuvar bir süreçtir. ... -
Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat
Memi, Gulsun; Yazgan, Burak (Wolters Kluwer Medknow Publications, 2021)Chronic kidney disease is one of the major global health problems. Chronic renal failure is stimulated by many cytokines and chemokines. Adropin and spexin (SPX) are peptides hormones. These peptides could affect inflammatory ... -
Adropin ve Speksin Peptitlerinin Kronik Renal Yetmezlik Modelinde Kardiyak COX ve LOX Gen Ekspresyonları Üzerine Etkisi
Yazgan, Burak; Memi, Gülsün (2022)Bu çalışmada adropin ve speksin peptitlerinin siklooksijenaz (COX) ve araşidonat lipooksijenaz (ALOX) gen ekspresyonları üzerindeki etkisinin kronik renal yetmezlik ekseninde gelişen kardiyak hasarda incelenmesi amaçlanmıştır. ... -
Akut miyokard infarktüsü hastalarında çöpçü reseptörler ve apoptotik proteinler arasındaki ilişkinin incelenmesi
Tahtalıoğlu, Sema (Amasya Üniversitesi, 2022)Kardiyovasküler hastalıklar serebrovasküler hastalıklar, anjina, ateroskleroz, koroner kalp hastalığı, miyokard infarktüsü ve kalp yetmezliği gibi vasküler ve kardiyak fonksiyonlardaki bir dizi bozukluktur. Kardiyovasküler ... -
Akut Miyokard İnfarktüsü Tedavi Sürecinde Rutin Biyokimya Parametreleri, Çöpçü Reseptörler ve Apoptotik Proteinler Arasındaki İlişkinin İncelenmesi
Bu çalışmada miyokard infarktüsü klinik tablosuna sahip hastalarda stent tedavi sürecinin çöpçü reseptörler ve apoptotik protein düzeylerine nasıl etki gösterdiğinin incelenmesi amaçlanmıştır. Bu amaçla koroner anjiyografide ... -
Analyses of the relationships among biofilm activity, antibiotic resistance and expressions of SHV, TEM, CTXand IntI in Klebsiella pneumoniae
Aim: Klebsiella pneumoniae as an opportunistic pathogen is responsible for nosocomial, urinary tract infections, pneumonia, bacteremia, liver abscesses, and respiratory and blood infections in patients. The aim of our study ... -
Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole Derivatives
Ayar, Arif; Aksahin, Masuk; Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: Pyrrole compounds having a heterocyclic structure are the most researched and biological activities such as antioxidant and anticancer activities. Objective: Herein is a first effort to study the significance ... -
ATP?Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds
Purpose: ABC proteins transport many substrates such as antibiotics and drugs. Increase of ABCs lead chemoresistance in can-cer.In view of this information, in our study, we planned to investigate both PhTAD-substituted ... -
Comparison of biofilm formation and efflux pumps in ESBL and carbapenemase producing Klebsiella pneumoniae
Yazgan, Burak; Turkel, Ibrahim; Guckan, Ridvan; Kilinc, Cetin; Yildirim, Tuba (J INFECTION DEVELOPING COUNTRIES, 2018)Introduction: Klebsiella pneumoniae is an opportunistic pathogen that causes a range of diseases. The appearance of extended-spectrum beta-lactamase-and carbapenemase-producing strains, in addition to the biofilm-forming ... -
Crystal structures of biogenic amine derivative Schiff bases, and these compounds modulatory effect on cell cycle arrest and cell death in lung cancer cells
Senkuytu, Elif; Davarci, Derya; Mesci, Seda; Yazgan, Burak (Elsevier, 2024)Cancer continues to be a global health problem, and this problem requires the development of targeted anticancer agents. Syntheses of different derivatives of Schiff bases have attracted serious attention in cancer research ... -
Cytotoxic and Apoptotic Effect ofIris taochia Plant Extracts on Human Breast Cancer (MCF-7) Cells
Yazgan, Burak; Ozcelik, Ozlem; Ayar, Arif; Renda, Gulin; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Introduction: Iris taochia is an endemic plant in Turkey. Iris species has many biological effects such as antibacterial, antiinflammatory, antioxidant and anticancer properties. Apoptosis is a programmed cell death and ... -
Downregulation of HSP27 by isoindole-derived pyrrolidines suppressing multidrug resistance (MDR) and inducing apoptosis in MCF-7 and DLD-1 cell lines
Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Natl Inst Science Communication-Niscair, 2024)In most cancer treatments, major problem arises from the prevention of cell death (apoptosis suppression) with the development of drug resistance. Anticancer agents that ensure elimination of drug resistance and drug-resistant ... -
Effects of MOTS-c Peptide on the Heart and Aorta in a Model of Cardiac Hypertrophy Induced by Abdominal Aorta Constriction
Memi, Gulsun; Turkel, Ibrahim; Annac, Ebru; Yazgan, Burak (Wiley, 2023)[Abstract Not Available] -
Effects of Sulfur Containing Glycine Imine Derivatives Compounds on Multidrug Resistance Proteins (MRPs) and Apoptosis Mechanism in MCF-7 and DLD-1 Cell Lines
Gül, Melek; Yıldırım, Tuba; Mesci, Seda; Yazgan, Burak; b, a (2022)Objective: Glutathione (GSH) is a tripeptide consisting of glycine, glutamic acid and cysteine. If the sulfur containing amino acids like methionine and cysteine increase in the cells, the level of GSH increases. GSH is ... -
EXAMINATION OF CORRELATIONS BETWEEN VITAMIN D AND MELATONIN LEVELS WITH SLEEP AMONG WOMEN AGED 18-49 YEARS
Sonkaya, Zehra Incedal; Yazgan, Burak; Kurtgoz, Asli; Demir, Aslihan Dilara; Irgat, Serap Incedal (Natl Inst Public Health, 2023)Objectives: Although clinical research is still going on to determine any relationship between vitamin D and sleep regulation, only few studies have identified the role of vitamin D metabolism in sleep disorders. The current ... -
Examination of Triazolinedione-Derived Dihydropyrrole Hybrid Compounds: ER Stress-Related Apoptosis in Breast Cancer Cells, Molecular Docking, and ADMET Analysis
Mesci, Seda; Ayar, Arif; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2024)Background In many types of cancer, uncontrolled growth and proliferation of cells occur due to abnormalities in their genes, mutations of pro-apoptotic proteins, or upregulation of anti-apoptotic proteins. Triazolinedione ... -
Exercise and Metabolic Health: The Emerging Roles of Novel Exerkines
Turkel, Ibrahim; Ozerklig, Berkay; Atakan, Muhammed M.; Aktitiz, Selin; Kosar, Sukran N.; Yazgan, Burak (Bentham Science Publ Ltd, 2022)Physical inactivity is a major cause of chronic diseases. It shortens the health span by lowering the age of the first chronic disease onset, which leads to decreased quality of life and increased mortality risk. On the ... -
Explorations of ATP-Binding Cassette Transporters and Apoptosis Signal Pathways of 2-Hydroxyanthraquinone Substituted Cyclotriphosphazenes in MCF-7 and DLD-1 Cell Lines
Yazgan, Burak; Mesci, Seda; Bayik, Nagihan; Aksahin, Masuk; Ciftci, Gonul Yenilmez; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: As a class with biological properties, such as anti-cancer, anti-bacterial, anti-HIV, and various physical effects, phosphazene derivatives constitute the most striking part of inorganic compounds. Anthraquinones, ... -
High Cholesterol Diet-Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue
Sozen, Erdi; Yazgan, Burak; Sahin, Ali; Ince, Umit; Ozer, Nesrin Kartal (HINDAWI LTD, 2018)Involvement of high cholesterol and oxidative stress in cardiovascular diseases is well studied, as it can be hypothesized that various products originated from lipid peroxidation, such as oxysterols, or affected protein ...
