Yazar "Mesci, Seda" için listeleme
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Analyses of the relationships among biofilm activity, antibiotic resistance and expressions of SHV, TEM, CTXand IntI in Klebsiella pneumoniae
Aim: Klebsiella pneumoniae as an opportunistic pathogen is responsible for nosocomial, urinary tract infections, pneumonia, bacteremia, liver abscesses, and respiratory and blood infections in patients. The aim of our study ... -
Antioxidant and Cytotoxic Activity Studies of Sulfur Containing Glycine Imine Derivatives MCF-7 and DLD-1 Cell Lines
Mesci, Seda; Gul, Melek; Yildirim, Tuba (Marmara Univ, Inst Health Sciences, 2021)Objective: To investigate the antioxidant and cytotoxic activities of sulfur-containing glycine imine derivatives MCF-7 (human breast adenocarcinoma) and DLD-1 (colorectal adenocarcinoma) cell lines. Methods: This study ... -
Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole Derivatives
Ayar, Arif; Aksahin, Masuk; Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: Pyrrole compounds having a heterocyclic structure are the most researched and biological activities such as antioxidant and anticancer activities. Objective: Herein is a first effort to study the significance ... -
Antiproliferative Activity of Pyrrolidine Derivatives compound in Colon Cancer Cells
Gül, Melek; Yıldırım, Tuba; Mesci, Seda (2022)Objective: Anti-cancer drug research plays an important role for chemotherapeutic treatments in various types of cancer. Pyrolidine derived compounds have been reported by many researchers to be a potent anti-cancer compound. ... -
ATP?Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds
Purpose: ABC proteins transport many substrates such as antibiotics and drugs. Increase of ABCs lead chemoresistance in can-cer.In view of this information, in our study, we planned to investigate both PhTAD-substituted ... -
Crystal structures of biogenic amine derivative Schiff bases, and these compounds modulatory effect on cell cycle arrest and cell death in lung cancer cells
Senkuytu, Elif; Davarci, Derya; Mesci, Seda; Yazgan, Burak (Elsevier, 2024)Cancer continues to be a global health problem, and this problem requires the development of targeted anticancer agents. Syntheses of different derivatives of Schiff bases have attracted serious attention in cancer research ... -
Downregulation of HSP27 by isoindole-derived pyrrolidines suppressing multidrug resistance (MDR) and inducing apoptosis in MCF-7 and DLD-1 cell lines
Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Natl Inst Science Communication-Niscair, 2024)In most cancer treatments, major problem arises from the prevention of cell death (apoptosis suppression) with the development of drug resistance. Anticancer agents that ensure elimination of drug resistance and drug-resistant ... -
Effects of Sulfur Containing Glycine Imine Derivatives Compounds on Multidrug Resistance Proteins (MRPs) and Apoptosis Mechanism in MCF-7 and DLD-1 Cell Lines
Gül, Melek; Yıldırım, Tuba; Mesci, Seda; Yazgan, Burak; b, a (2022)Objective: Glutathione (GSH) is a tripeptide consisting of glycine, glutamic acid and cysteine. If the sulfur containing amino acids like methionine and cysteine increase in the cells, the level of GSH increases. GSH is ... -
Examination of Triazolinedione-Derived Dihydropyrrole Hybrid Compounds: ER Stress-Related Apoptosis in Breast Cancer Cells, Molecular Docking, and ADMET Analysis
Mesci, Seda; Ayar, Arif; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2024)Background In many types of cancer, uncontrolled growth and proliferation of cells occur due to abnormalities in their genes, mutations of pro-apoptotic proteins, or upregulation of anti-apoptotic proteins. Triazolinedione ... -
Explorations of ATP-Binding Cassette Transporters and Apoptosis Signal Pathways of 2-Hydroxyanthraquinone Substituted Cyclotriphosphazenes in MCF-7 and DLD-1 Cell Lines
Yazgan, Burak; Mesci, Seda; Bayik, Nagihan; Aksahin, Masuk; Ciftci, Gonul Yenilmez; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: As a class with biological properties, such as anti-cancer, anti-bacterial, anti-HIV, and various physical effects, phosphazene derivatives constitute the most striking part of inorganic compounds. Anthraquinones, ... -
The first synthesis and characterization of spiro and ansa-cyclotriphosphazenes with 3-Hydroxyflavone and induction of apoptosis in breast cancer (MCF-7)
Ciftci, Gonul Yenilmez; Koksal, Burak; Kitmur, Ibrahim; Mesci, Seda; Ay, Ebru Bati; Yildirim, Tuba (Elsevier, 2024)In this study, the first series of 3-Hydroxyflavone substituted spiro, ansa-1,3-propanedioxy and 2,2-dimethyl 1,3propanedioxy substituted cyclotriphosphazene compounds 912 were synthesized and their structures were ... -
Investigation of antioxidant activity and effect on cell viability of pyrrolidine compounds in MCF-7 (breast cancer) and DLD-1 (colon cancer) cell lines
Mesci, Seda; Gul, Melek; Yildirm, Tuba (Al-Farabi Kazakh Natl Univ, 2021)In this study, it is aimed to investigate the effects of pyrrolidine compounds that are thought to be new drug candidates with effect on cell viability on cancer (MCF-7 and DLD-1) and normal (MCF-12A and CCD-18CO) cell ... -
İzoindol türevli bileşiklerin insan meme ve kolon kanseri hücrelerinde çoklu ilaç direncine ve apoptotik sinyal yolaklarına etkilerinin belirlenmesi
Mesci, Seda (Amasya Üniversitesi, 2020)Meme kanseri kadınlar arasında en yaygın görülen kanser türüdür ve dünya çapında tüm kanserlerin yaklaşık dörtte birini oluşturmaktadır. Kolon kanseri ise erkeklerde ve kadınlarda en çok rastlanan kanser türüdür. Bu ... -
Novel antipyrine substituted 4-thiazolidinones: Synthesis, DNA binding and topoisomerase inhibition activities, and in-silico studies
Bagdatli, Emine; Mesci, Seda; Yildirim, Tuba (Elsevier, 2024)In this study, we report the synthesis and characterization of novel 4-thiazolidinones containing antipyrine (3ae) derived from the starting compounds of Schiff bases (2a-e). The Schiff bases were synthesized using aldehydes ... -
PhTAD-Substituted Dihydropyrrole Compounds Regulate Apoptotic Cell Death in MCF-7 Cells
Breast cancer is the most common type of cancer amongst women. Apoptosis is known as a programmed cell death and this mechanism induces cancer cell death. Dihydropyrrole compounds contain a heterocyclic structure and these ... -
Zinc and phosphorus fertilization in Galanthus elwesii Hook: Changes in the total alkaloid, flavonoid, and phenolic content, and evaluation of anti-cancer, anti-microbial, and antioxidant activities
Ay, Ebru Bati; Acikgoz, Muhammed Akif; Kocaman, Beril; Mesci, Seda; Kocaman, Berna; Yildirim, Tuba (Elsevier, 2023)Galanthus elwesii Hook belongs to the Amaryllidaceae family and is an ornamental plant that naturally spreads in the region between Turkey and Europe. It also contains bioactive compounds in the nutraceutical and phar-maceutical ...
