Browsing by Author "Gül, Melek"

Antipirin türevli bileşiklerin biyolojik önemi

Budak, Mukaddes (Amasya Üniversitesi, 2022)

Son yıllarda, çok çeĢitli heterohalkalı bileĢikler anahtar olarak seçilerek türevlendirme tepkimeleri ile onların biyolojik aktivite gösterecek yapılara dönüĢtürülmeleri Ģeklindeki çalıĢmalar hızla artmıĢtır. Ġlaç aktif ...

Antiproliferative Activity of Pyrrolidine Derivatives compound in Colon Cancer Cells

Gül, Melek; Yıldırım, Tuba; Mesci, Seda (2022)

Objective: Anti-cancer drug research plays an important role for chemotherapeutic treatments in various types of cancer. Pyrolidine derived compounds have been reported by many researchers to be a potent anti-cancer compound. ...

ATP?Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds

Gül, Melek; Yıldırım, Tuba; Mesci, Seda; Yazgan, Burak; Ayar, Arif; Aksahin, Masuk (2022)

Purpose: ABC proteins transport many substrates such as antibiotics and drugs. Increase of ABCs lead chemoresistance in can-cer.In view of this information, in our study, we planned to investigate both PhTAD-substituted ...

Effects of Sulfur Containing Glycine Imine Derivatives Compounds on Multidrug Resistance Proteins (MRPs) and Apoptosis Mechanism in MCF-7 and DLD-1 Cell Lines

Gül, Melek; Yıldırım, Tuba; Mesci, Seda; Yazgan, Burak; b, a (2022)

Objective: Glutathione (GSH) is a tripeptide consisting of glycine, glutamic acid and cysteine. If the sulfur containing amino acids like methionine and cysteine increase in the cells, the level of GSH increases. GSH is ...

Enzymatic Synthesis and Functionalization of 2-Aminofluorene-Based Compounds with Multi-Walled Carbon Nanotubes (MWCNT) for Enhanced Performance in Organic Solar Cells

Canımkurbey, Betül; Taş, Recep; Gül, Melek (Osmaniye Korkut Ata Üniversitesi, 2025)

This research focuses on the synthesis and characterization of 2-Aminofluorene (PAF)-based compounds for their potential application in organic solar cells (OSCs). We present a novel enzymatic approach to the synthesis of ...

THE INVESTIGATION OF SPECTROSCOPIC AND THEORETICAL METHODS OF BISISOXAOLINE DERIVATIVE OF NORBORNADIEN

Eryılmaz, Serpil; Mesci, Kerem; Gül, Melek; İnkaya, Ersin (Eskisehir Technical University, 2016)

In this study, the synthesis of bisisoxaoline derivative of norbornadien from heterocyclic compounds was performed via 1,3-dipolar cycloaddition reaction, the structural properties of derivative characterized by spectroscopic ...

Investigation of the effects of lycorine and galanthamine extracted from Galanthus elwesii on viral and parasitic targets: An in-silico analysis and DFT Study

Gül, Melek; Ay, Ebru Batı (Muhammet DOĞAN, 2024)

In this study, Density Functional Theory (DFT), ADME property analysis, and molecular docking simulations were employed to evaluate the electronic structure, antiviral potential, and antiparasitic effects of lycorine and ...