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2-Hydroxyanthraquinone substituted cyclotriphosphazenes: Synthesis and cytotoxic activities in cancer cell lines
Ciftci, Gonul Yenilmez; Demir, Gizem; Senkuytu, Elif; Ecik, Esra Tanriverdi; Aksahin, Masuk; Yildirim, Tuba (Elsevier Science Sa, 2021)Scientists continue to synthesize substances that have cytotoxic effects and examine their properties to overcome cancer for a long time. This study is aimed at preparing novel cyclotriphosphazene derivatives and examining ... -
The bioactive new type paraben decorated dispiro-cyclotriphosphaze compounds: synthesis, characterization and cytotoxic activity studies
Senkuytu, Elif; Akbas, Nadide; Yildirim, Tuba; Ciftci, Gonul Yenilmez (Elsevier, 2022)Cancer is a leading cause of death worldwide and hence studies to find anti-cancer agents for its treatment continue to grow in importance. Generally, cytotoxic drugs have been used for cancer treatment in susceptible ... -
Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene-Bridged Cyclophosphazenes
Yildirim, Tuba; Senkuytu, Elif; Ergene, Emel; Bilgin, Kemal; Uludag, Yildiz; Ciftci, Gonul Yenilmez (WILEY-V C H VERLAG GMBH, 2018)In this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass ... -
DNA interaction analysis of fluorenylidene double bridged cyclotriphosphazene derivatives
Senkuytu, Elif; Yildirim, Tuba; Olcer, Zehra; Uludag, Yildiz; Ciftci, Gonul Yenilmez (ELSEVIER SCIENCE SA, 2018)DNA is a target molecule for anticancer drug development, and investigation on DNA interactions with synthesized potential drugs has great importance in order to discover new drug candidates, hence in this study an ... -
Explorations of ATP-Binding Cassette Transporters and Apoptosis Signal Pathways of 2-Hydroxyanthraquinone Substituted Cyclotriphosphazenes in MCF-7 and DLD-1 Cell Lines
Yazgan, Burak; Mesci, Seda; Bayik, Nagihan; Aksahin, Masuk; Ciftci, Gonul Yenilmez; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)Background: As a class with biological properties, such as anti-cancer, anti-bacterial, anti-HIV, and various physical effects, phosphazene derivatives constitute the most striking part of inorganic compounds. Anthraquinones, ... -
First paraben substituted cyclotetraphosphazene compounds and DNA interaction analysis with a new automated biosensor
Ciftci, Gonul Yenilmez; Senkuytu, Elif; Incir, Saadet Elif; Yuksel, Fatma; Olcer, Zehra; Yildirim, Tuba; Kilic, Adem; Uludag, Yildiz (ELSEVIER ADVANCED TECHNOLOGY, 2016)Cancer, as one of the leading causes of death in the world, is caused by malignant cell division and growth that depends on rapid DNA replication. To develop anti-cancer drugs this feature of cancer could be exploited by ... -
Synthesis and characterization of new cyclotriphosphazene compounds
Ciftci, Gonul Yenilmez; Ecik, Esra Tannverdi; Yildirim, Tuba; Bilgin, Kemal; Senkuytu, Elif; Yuksel, Fatma; Uludag, Yildiz; Kilic, Adem (PERGAMON-ELSEVIER SCIENCE LTD, 2013)In the present study, Spiro (1a), dispiro (1b, 2, 3), per-substituted spermine-bridged (6-9) and dispiroansa spermine (10) derivatives of cyclotriphosphazene have been synthesized. The structures of the novel compounds ... -
Synthesis, characterization and cytotoxic activity studies on cancer cell lines of new paraben-decorated monospiro-cyclotriphosphazenes
Senkuytu, Elif; Akbas, Nadide; Yildirim, Tuba; Ciftci, Gonul Yenilmez (Royal Soc Chemistry, 2022)Cancer is one of the Leading causes of death worldwide. Among the causes of cancer-related deaths in women, breast cancer, which is the most common type of cancer in women, is in second place. On the other hand, colon ... -
Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents
Yildirim, Tuba; Bilgin, Kemal; Ciftci, Gonul Yenilmez; Ecik, Esra Tanriverdi; Senkuytu, Elif; Uludag, Yildiz; Tomak, Leman; Kilic, Adem (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2012)In the present study, a number of new dispirobino and dispiroansa spermine derivatives of cyclotriphosphazene (8-10, 13) were synthesized and characterized by elemental analysis, mass spectrometry, H-1 and P-31 NMR ...
