Yazar "Aydin, Birsen" için listeleme
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3-Imino derivative-sulfahydantoins: Synthesis, in vitro antibacterial and cytotoxic activities and their DNA interactions
Baskan, Ceren; Erturk, Aliye Gediz; Aydin, Birsen; Siriken, Belgin (Academic Press Inc Elsevier Science, 2022)Sulfahydantoins are five-membered rings found in the structure of chemicals that exhibit antibacterial, antiinflammatory, and anticonvulsant properties. They also activate serine protease enzymes that catalyze the hydrolysis ... -
Acrolein-induced oxidative stress and genotoxicity in rats: protective effects of whey protein and conjugated linoleic acid
Aydin, Birsen; Sekeroglu, Zuelal Atli; Sekeroglu, Vedat (TAYLOR & FRANCIS LTD, 2018)Acrolein (AC), a highly reactive hazardous pollutant, poses serious threats to human health. Whey protein (WP) and conjugated linoleic acid (CLA) have beneficial health implications. We investigated the protective effects ... -
The Antioxidant and Antigenotoxic Effects of Pycnogenol (R) on Rats Treated With Cisplatin
Aydin, Birsen; Unsal, Meftun; Sekeroglu, Zulal A.; Gulbahar, Yavuz (HUMANA PRESS INC, 2011)Oxidative stress and inflammation are implicated in the pathogenesis of cisplatin-induced toxicity. PycnogenolA (R) is known for its strong antioxidant and anti-inflammatory effects. In this study, the possible protective ... -
Argan oil reduces oxidative stress, genetic damage and emperipolesis in rats treated with acrylamide
Sekeroglu, Zulal Atli; Aydin, Birsen; Sekeroglu, Vedat (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017)Acrylamide (AA), a well-known toxicant, is present in high-temperature-processed foods in heated foods. Argan oil (AO), a natural vegetable oil, is receiving increasing attention due to its powerful biological properties. ... -
Cerium oxide nanoparticles exert antitumor effects and enhance paclitaxel toxicity and activity against breast cancer cells
Sekeroglu, Zulal Atli; Sekeroglu, Vedat; Aydin, Birsen; Yedier, Seval Kontas (Wiley, 2023)Cerium oxide nanoparticles (CeONPs) displayed cytotoxic properties against some cancer cells. However, there is very limited data about the possible antitumoral potential of them in breast cancer cells when used alone ... -
Conjugated linoleic acid protects brain mitochondrial function in acrolein induced male rats
Aydin, Birsen; Guler Sahin, Cansu; Sekeroglu, Vedat; Atli Sekeroglu, Zulal (Taylor & Francis Ltd, 2021)Acrolein (AC) is a toxic substance that can have a neurotoxic effect. It can cause oxidative stress and mitochondrial dysfunction. Conjugated linoleic acid (CLA), a dietary supplement, has many biological functions. Limited ... -
Cytotoxic, genotoxic, and carcinogenic effects of acrylamide on human lung cells
Yedier, Seval Kontas; Sekeroglu, Zlal Atli; Sekeroglu, Vedat; Aydin, Birsen (Pergamon-Elsevier Science Ltd, 2022)While an association between acrylamide (AC) exposure and the risk of developing cancer has been shown in some studies, there are very limited data on the relationship between AC exposure and lung cancer risk. Thus, we ... -
Cytotoxicity and genotoxicity of clothianidin in human lymphocytes with or without metabolic activation system
Sekeroglu, Zulal Atli; Sekeroglu, Vedat; Ucgun, Ebru; Yedier, Seval Kontas; Aydin, Birsen (TAYLOR & FRANCIS LTD, 2019)Clothianidin (CHN) is a broad-spectrum neonicotinoid insecticide. Limited studies have been carried out on the cytotoxic and genotoxic effects of both CHN using different genotoxicity tests in human cells with or without ... -
Effects of a 900-MHz Electromagnetic Field on Oxidative Stress Parameters in Rat Lymphoid Organs, Polymorphonuclear Leukocytes and Plasma
Aydin, Birsen; Akar, Aysegul (ELSEVIER SCIENCE INC, 2011)Background and Aims. The present study investigated the effects of a 900-MHz electromagnetic field (EMF) for 2 h/day for 45 days on lymphoid organs (spleen, thymus, bone marrow), polymorphonuclear leukocytes (PMNs) and ... -
Effects of argan oil on the mitochondrial function, antioxidant system and the activity of NADPH- generating enzymes in acrylamide treated rat brain
Aydin, Birsen (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017)Argan oil (AO) is rich in minor compounds such as polyphenols and tocopherols which are powerful antioxidants. Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans. Mitochondrial oxidative stress ... -
Effects of tartrazine on proliferation and genetic damage in human lymphocytes
Sekeroglu, Zulal Atli; Gunes, Busra; Yedier, Seval Kontas; Sekeroglu, Vedat; Aydin, Birsen (TAYLOR & FRANCIS LTD, 2017)The color additive, tartrazine (TRZ), is widely used in food products, drugs and cosmetics. Genotoxicity of TRZ and its metabolites has not been investigated in detail in the presence and absence of a metabolic activator ... -
Effects of thiacloprid, deltamethrin and their combination on oxidative stress in lymphoid organs, polymorphonuclear leukocytes and plasma of rats
Aydin, Birsen (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)Deltamethrin and thiachloprid are an alpha-cyano class pyrethroid and neonicotinoid insecticide, respectively. Recently, a pesticide combining deltamethrin and thiacloprid has also been released. In the present study, the ... -
Effects of whey protein and conjugated linoleic acid on acrolein-induced cardiac oxidative stress, mitochondrial dysfunction and dyslipidemia in rats
Aydin, Birsen; Sekeroglu, Zulal Atli; Sekeroglu, Vedat (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2018)Acrolein is a ubiquitous environmental pollutant. Whey protein and conjugated linoleic acid are widely used weight-loss supplements. We aimed to evaluate blood lipid profiles, oxidative stress and mitochondrial bioenergetics ... -
Hepatoprotective effects of capsaicin and alpha-tocopherol on mitochondrial function in mice fed a high-fat diet
Sekeroglu, Vedat; Aydin, Birsen; Sekeroglu, Zulal Atli; Kompe, Yasemin Ozdener (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2018)Capsaicin (CAP) and alpha-tocopherol (TOC) have antioxidant properties. We investigated effects of CAP and TOC on mitochondrial oxidative stress and mitochondrial bioenergetics in liver of mice fed HFD. AST, ALT, glucose, ... -
Trimetazidine alone or in combination with gemcitabine and/or abraxane decreased cell viability, migration and ATP levels and induced apoptosis of human pancreatic cells
Sekeroglu, Vedat Atli; Sekeroglu, Vedat; Isik, Sevil; Aydin, Birsen (Elsevier Masson, Corp Off, 2021)Background: Trimetazidine (TMZ) is an anti-ischemic agent that can inhibit the fatty acid oxi-dation. It has been stated that inhibition of fatty acid oxidation may be an acceptable approach to cancer treatment. Methods: ... -
Viscum album L. Extract and Quercetin Reduce Cyclophosphamide-Induced Cardiotoxicity, Urotoxicity and Genotoxicity in Mice
Sekeroglu, Vedat; Aydin, Birsen; Sekeroglu, Zulal Atli (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2011)Possible protective effects of a methanolic extract of Viscum album (VA) and quercetin (QE) against cyclophosphamide (CP) induced cardiotoxicity, urotoxicity and genotoxicity in mice were evaluated. Mice were administered ... -
Whey protein protects liver mitochondrial function against oxidative stress in rats exposed to acrolein
Aydin, Birsen; Oguz, Ali; Sekeroglu, Vedat; Sekeroglu, Zulal Atli (Sciendo, 2022)Acrolein (AC) is one of the most toxic environmental pollutants, often associated with incomplete combustion of petrol, wood, and plastic, oil frying, and tobacco smoking, that causes oxidative damage to DNA and mitochondria. ...
