Automatic Segmentation of the Cerebellum in Healthy Individuals: A volBrain (CERES) Study

Abstract

ABSTRACT Aim: We aimed to investigate the total cerebellum volume and the volume of healthy individuals' right and left cerebellum lobes according to age groups and sex. Methods: 3T T1-weighted Magnetic Resonance Images of 200 individuals (100 female, 100 male) of both sexes between the ages of 18-78 were included in our study. Total cerebellum volume and volume results of cerebellum lobules will be calculated from these images with the sub-tab CERES of the volBrain software program. Results: The total cerebellum volume in our study was found to be 115.41±12.25 cm3 in females and 126.27±14.78 cm3 in males, and the values were statistically significant (p<0.001). The right side lobule I-II, lobule IV, lobule crus II, lobule VIIB, lobule VIIIA and lobule X values of the cerebellum were statistically higher than the left side (p<0.05). On the left side, lobule V, VIIIB and IX values were statistically higher than the right side (p<0.05). When evaluated according to sex, the values of males were statistically higher than females in all parameters except for the total lobule I-II, right lobule I-II, left lobule I-II, right lobule V, total lobule VI and right lobule VI values (p<0.05). According to age groups, except for total lobule I-II, right lobule I-II and left lobule I-II values, all other parameters were statistically lower in the 50-year-old and above group than in the under-50-year-old group (p<0.05). Conclusion: We believe that knowing the total cerebellum volume and volumetric analysis of its lobules in healthy adults will define the disease group and its prognosis.