Evaluation of systemic immune-inflammation index, systemic inflammatory response index and hematologic inflammatory parameters in generalized anxiety disorder: a controlled study

Abstract

Aims: The current study aimed to examine the values of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) in generalized anxiety disorder (GAD). Methods: In this retrospective study, 147 GAD patients who did not receive treatment and 154 healthy controls with similar characteristics to the patient group were included. NLR, PLR, MLR, SII, and SIRI values calculated from the complete blood count values of the GAD group were compared with age- and sex-matched healthy controls. Results: Neutrophil, lymphocyte, monocyte, platelet counts and NLR, MLR, SII, and SIRI values were significantly higher in the GAD group compared to healthy controls (p<0.001, p=0.001, p<0.001, p<0.001, p<0.001, p=0.003, p<0.001, p<0.001, respectively). The logistic regression analysis revealed that SII and SIRI were identified as significant variables associated with receiving a diagnosis of GAD. Conclusion: Inflammatory markers such as NLR, MLR, SII, and SIRI are thought to play an important role in the evaluation of inflammatory activity in GAD. However, larger and more comprehensive studies are needed.