The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast

Abstract

Objective: It is estimated that the use of wrong laxatives will increase the probability of developing an eating disorder by affecting the disorder in eating behavior and the physiological disorder of digestion. Long-term use of laxatives is known by many to impair normal colonic function and producing laxative dependence. In our study, it was aimed to determine the effect of the Folliculj sennae plant, which is used for laxative and slimming purposes, on the CCD-18Co (healthy colon fibroblast) cell line. Materials and Methods: The effect of Folliculj sennae plant. Its antiproliferative effect on CCD-18Co cell line was determined by MTT test. Results: According to the concentrations used in the CCD-18Co cell line, the % viability activities were determined between 73 and 54 and the 50% inhibitory concentration value (IC50) was calculated as 47 mg/ml. Conclusion: It is thought that the Folliculj sennae plant, which is used as a laxative and has a negative effect on the CCD18-Co cell line, will make an important contribution by health professionals to raise the awareness of their patients about laxatives.