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dc.contributor.authorSekeroglu, Zulal Atli
dc.contributor.authorSekeroglu, Vedat
dc.contributor.authorAydin, Birsen
dc.contributor.authorYedier, Seval Kontas
dc.date.accessioned2024-03-12T19:28:47Z
dc.date.available2024-03-12T19:28:47Z
dc.date.issued2023
dc.identifier.issn1552-4973
dc.identifier.issn1552-4981
dc.identifier.urihttps://doi.org/10.1002/jbm.b.35175
dc.identifier.urihttps://hdl.handle.net/20.500.12450/2043
dc.description.abstractCerium oxide nanoparticles (CeONPs) displayed cytotoxic properties against some cancer cells. However, there is very limited data about the possible antitumoral potential of them in breast cancer cells when used alone and/or together with a chemotherapeutic drug. We investigated the effects of CeONPs alone or in combination with paclitaxel (PAC) on healthy or carcinoma breast cells. After human breast cancer cells (MCF-7) treated with CeONPs alone or together with PAC for 24, 48, and 72 h, the effects of CeONPs on cell viability, apoptosis, migration, and adhesion were investigated. All cell viability and IC50 values of CeONPs and PAC treatments in healthy breast cells (HTERT-HME1) were higher than MCF-7 cells. They showed higher cytotoxicity against MCF-7 cells. CeONPs (10, 20, and 30 mM) and/or abraxane (AB) (2 mu M) significantly decreased cell viability values in MCF-7 cells. All CeONPs concentrations increased the number of apoptotic MCF-7 cells. CeONPs (20 and 30 mM) alone or in combination with AB for 72 h treatment also significantly increased the apoptosis in compared to AB alone. CeONPs and/or AB can significantly inhibit the migratory ability of breast cancer cells. The migration rates in co-treated groups with CeONPs and AB were lower than CeONPs treatments. Higher concentrations of CeONPs alone or together with AB inhibited cell adhesion. Our results showed CeONPs can increase cytotoxicity and apoptosis and decrease cell migration and cell adhesion when used alone or together with AB. Therefore, combination of chemotherapeutics with CeONPs may provide a good strategy against cancer.en_US
dc.description.sponsorshipScientific Research Funding of Funding of Amasya University (Turkey) [FMB-BAP-17-0249]; Scientific Research Funding of Ordu University (Turkey) [A-2014]en_US
dc.description.sponsorshipScientific Research Funding of Funding of Amasya University (Turkey), Grant/Award Number: FMB-BAP-17-0249; Scientific Research Funding of Ordu University (Turkey), Grant/Award Number: A-2014en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biomedical Materials Research Part B-Applied Biomaterialsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadhesionen_US
dc.subjectapoptosisen_US
dc.subjectbreast canceren_US
dc.subjectcerium oxide nanoparticlesen_US
dc.subjectmigrationen_US
dc.subjectpaclitaxelen_US
dc.titleCerium oxide nanoparticles exert antitumor effects and enhance paclitaxel toxicity and activity against breast cancer cellsen_US
dc.typearticleen_US
dc.departmentAmasya Üniversitesien_US
dc.authoridSekeroglu, Zulal Atli/0000-0002-3552-3819
dc.identifier.volume111en_US
dc.identifier.issue3en_US
dc.identifier.startpage579en_US
dc.identifier.endpage589en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-85142263540en_US
dc.identifier.doi10.1002/jbm.b.35175
dc.department-temp[Sekeroglu, Zulal Atli; Sekeroglu, Vedat; Yedier, Seval Kontas] Ordu Univ, Fac Sci & Letters, Dept Mol Biol & Genet, TR-52200 Ordu, Turkey; [Aydin, Birsen] Amasya Univ, Fac Med, Fac Sci & Letters, Dept Biol, Amasya, Turkeyen_US
dc.identifier.wosWOS:000866098300001en_US
dc.identifier.pmid36221929en_US
dc.authorwosidSekeroglu, Zulal Atli/M-3525-2013


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