https://hdl.handle.net/20.500.12450/1683 Research Outputs | TR-Dizin | WoS | Scopus | PubMed 2026-04-19T02:34:28Z https://hdl.handle.net/20.500.12450/6166 Mechanisms Underlying the Use of Abusive and Neglectful Behaviors in Dementia Caregiving The Role of Caregiver Mental Health Browning, Wesley R.; Yildiz, Mustafa; Chilatra, Jessica A. Hernandez; Yefimova, Maria; Maxwell, Christopher D.; Sullivan, Tami P.; Winstead, Vicki PURPOSE: In dementia family caregiving, caregiver psychopathology has been frequently identified as a possible risk factor for the use of physically abusive, psychologically abusive, and neglectful behaviors toward care recipients. Yet, the mechanistic role of psychopathology in the use of these behaviors is not understood. The purpose of the current study is to determine the role of caregiver mental health in their daily risk of engaging in physically and psychologically aggressive and neglectful behaviors toward their care recipient with dementia. METHOD: We used an intensive longitudinal design to survey family caregivers daily over 21 days. Using generalized linear mixed models, we evaluated the differential impact of caregivers'(N = 453) experience of major depression and generalized anxiety disorders measured at baseline versus 9,513 daily ratings of depressive and anxiety symptom severity, and interactions across levels, on the daily odds of engaging in physically abusive, psychologically abusive, and neglectful behaviors. RESULTS: Caregivers with clinically significant depression or anxiety at baseline had higher daily odds of engaging in each type of abusive and neglectful behavior. Worsened depressive symptoms (compared to individuals'average across all days) on a given day were associated with increased odds of engaging in psychologically and physically aggressive behaviors on the same day. Worsened anxiety symptoms on a given day were associated with increased odds of psychologically aggressive and neglectful behaviors. CONCLUSION: A key finding was lack of a significant interaction effect between depression and anxiety disorders and mental health symptomology on the daily odds of engaging in abusive and neglectful behaviors. This finding indicates that daily depressive and anxiety symptoms are generalizable intervention targets across the family caregiver population and do not only increase risk among family caregivers with depressive and anxiety disorders. [ Research in Gerontological Nursing, 17 (5), 227-236.] 2024-01-01T00:00:00Z https://hdl.handle.net/20.500.12450/6165 IMPACT OF MANGANESE HYDROXYCHLORIDE ON EGG QUALITY, ANTIOXIDANT CAPACITY, BONE CHARACTERISTICS, AND MINERAL EXCRETION IN LAYING QUAIL Olgun, Osman; Kilinc, Gozde; Gul, Esra Tugce; Gokmen, Fatih; Yildiz, Alponder; Uygur, Veli; Sevim, Behlul This research investigated the impact of different concentrations of manganese hydroxychloride (MnH) on productive performance, egg quality, antioxidant status, tibia characteristics, and mineral excretion in laying quails. A total of 125 female ten-week-old female quails, were divided into five groups with five subgroups, each containing five quails. The birds were fed isoenergetic and isonitrogenous diets with different levels of MnH (containing 55 g/100 g Mn) at 18.86 mg/kg (basal diet), 40, 60, 80, and 100 mg/kg for twelve weeks. Results indicated that MnH supplementation enhanced egg production and feed intake (P < 0.05) compared to the non-supplemented group. The optimal eggshell quality, including shell- breaking strength, thickness, and weight, was observed at 80 mg/kg MnH (P<0.01) compared to the basal diet. Regarding the antioxidant capacity in the yolk, the yolk's 2,2- diphenyl-1-picrylhydrazyl (DPPH) value increased significantly (P<0.01) with 100 mg/kg MnH supplementation, while malondialdehyde (MDA) values remained unaffected across all groups. Increasing dietary MnH levels elevated Mn excretion in faeces and reduced copper levels (P<0.01). However, MnH addition adversely affected tibia biomechanical properties compared to the basal diet (P<0.01), with no significant impact on tibia mineral accumulation (P>0.05). These results suggest that including 80 mg/kg MnH in laying quail diets would be adequate to improve certain aspects of production and eggshell quality, although its impact on bone parameters requires further investigation. 2024-01-01T00:00:00Z https://hdl.handle.net/20.500.12450/6164 Synthesis, Enzyme Inhibition, and in Silico Studies of Amino Acid Schiff Bases Tas, Nilay Akkus; Senocak, Aysegul; Taslimi, Parham; Tuzun, Burak; Karadag, Ahmet In this research, novel complexes of Zn(II) were produced using amino acid Schiff bases. First, new Schiff bases were synthesized from the reaction of 3-methoxy-2-hydroxybenzaldehyde (o-vanillin) and amino acid methyl esters (isoleucine, phenylalanine, methionine). The synthesis of new complexes was carried out by the reaction of these Schiff bases and Zn(OAc)(2).2H(2)O. The structures of the synthesized complexes were elucidated using elemental analysis, FT-IR, NMR, UV-vis spectroscopy, and thermal analysis techniques. In this research, we synthesized new complexes of Zn(II) with amino acid Schiff bases labeled as 1a-1c. We then examined their impact on specific metabolic enzymes, namely acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results showed that the molecules exhibited potent inhibitory activities against all targets compared to the standard inhibitor as indicated by IC50 values. Ki values of the compounds for AChE and BChE enzymes were obtained in the range of 78.04 +/- 8.66-111.24 +/- 12.61 and 24.31 +/- 3.98-85.18 +/- 7.05 mu M, respectively. Molecular docking calculations were performed to investigate the biological activities of the metal complexes. The Protein Ligand Interaction Profiler (PLIP) was used to study the chemical interactions of metal complexes with enzymes. 2024-01-01T00:00:00Z https://hdl.handle.net/20.500.12450/6161 Experimental Investigation of Biodiesel and Acetylene Dual Fuel Use in a Diesel Engine with RCCI Approach Ors, Ilker; Sarikoc, Selcuk; Yelbey, Savas Diesel engines are widely used in road, railway and sea transportation and electricity generation because they can provide high torque with low fuel consumption. Today, the increase in the cost of petroleum-based diesel fuel and the decrease in petroleum reserves day by day have brought biodiesel to the fore as an alternative diesel fuel. Biodiesel also has a limited area of use due to its cost and low performance values. In addition, very high NOx emission and feedstock problem can be added to these disadvantages. In this study, it is aimed to both reduce the harm of waste oil to nature and solve the feedstock problem by choosing waste cooking oil (from university cafeterias) as a biodiesel raw material. In addition, 30% acetylene was added to meet the engine's energy need as a dual fuel technology in order to increase the preference for the use of biodiesel in diesel engines. The experiments were carried out at 4 different engine loads (15 Nm, 30 Nm, 45 Nm and 60 Nm) and a 3-cylinder naturally aspirated diesel engine. According to the test results obtained, biodiesel fuel consumption was reduced by 30% with the addition of 10% acetylene. In addition, reductions of 6.85%, 10.41%, 8.1% and 5.61%, respectively, were detected in CO, HC, NOx emission and smoke opacity values. 6th EurAsia Waste Management Symposium (EWMS) -- OCT 24-26, 2022 -- Istanbul, TURKEY 2022-01-01T00:00:00Z