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Quorum sensing systems and related virulence factors in Pseudomonas aeruginosa isolated from chicken meat and ground beef 

Inat, Gokhan; Siriken, Belgin; Baskan, Ceren; Erol, Irfan; Yildirim, Tuba; Ciftci, Alper (Nature Portfolio, 2021)
The objective of this study was to evaluate 50 [chicken meat (n=45) and ground beef (n=5)] Pseudomonas aeruginosa isolates to determine the expression of the lasI and rhl QS systems, related virulence factors, and the ...

Antioxidant and Cytotoxic Activity Studies of Sulfur Containing Glycine Imine Derivatives MCF-7 and DLD-1 Cell Lines 

Mesci, Seda; Gul, Melek; Yildirim, Tuba (Marmara Univ, Inst Health Sciences, 2021)
Objective: To investigate the antioxidant and cytotoxic activities of sulfur-containing glycine imine derivatives MCF-7 (human breast adenocarcinoma) and DLD-1 (colorectal adenocarcinoma) cell lines. Methods: This study ...

Zinc and phosphorus fertilization in Galanthus elwesii Hook: Changes in the total alkaloid, flavonoid, and phenolic content, and evaluation of anti-cancer, anti-microbial, and antioxidant activities 

Ay, Ebru Bati; Acikgoz, Muhammed Akif; Kocaman, Beril; Mesci, Seda; Kocaman, Berna; Yildirim, Tuba (Elsevier, 2023)
Galanthus elwesii Hook belongs to the Amaryllidaceae family and is an ornamental plant that naturally spreads in the region between Turkey and Europe. It also contains bioactive compounds in the nutraceutical and phar-maceutical ...

2-Hydroxyanthraquinone substituted cyclotriphosphazenes: Synthesis and cytotoxic activities in cancer cell lines 

Ciftci, Gonul Yenilmez; Demir, Gizem; Senkuytu, Elif; Ecik, Esra Tanriverdi; Aksahin, Masuk; Yildirim, Tuba (Elsevier Science Sa, 2021)
Scientists continue to synthesize substances that have cytotoxic effects and examine their properties to overcome cancer for a long time. This study is aimed at preparing novel cyclotriphosphazene derivatives and examining ...

Explorations of ATP-Binding Cassette Transporters and Apoptosis Signal Pathways of 2-Hydroxyanthraquinone Substituted Cyclotriphosphazenes in MCF-7 and DLD-1 Cell Lines 

Yazgan, Burak; Mesci, Seda; Bayik, Nagihan; Aksahin, Masuk; Ciftci, Gonul Yenilmez; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)
Background: As a class with biological properties, such as anti-cancer, anti-bacterial, anti-HIV, and various physical effects, phosphazene derivatives constitute the most striking part of inorganic compounds. Anthraquinones, ...

Cytotoxic and Apoptotic Effect ofIris taochia Plant Extracts on Human Breast Cancer (MCF-7) Cells 

Yazgan, Burak; Ozcelik, Ozlem; Ayar, Arif; Renda, Gulin; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)
Introduction: Iris taochia is an endemic plant in Turkey. Iris species has many biological effects such as antibacterial, antiinflammatory, antioxidant and anticancer properties. Apoptosis is a programmed cell death and ...

Antioxidant, Cytotoxic Activity and Pharmacokinetic Studies by Swiss Adme, Molinspiration, Osiris and DFT of PhTAD-substituted Dihydropyrrole Derivatives 

Ayar, Arif; Aksahin, Masuk; Mesci, Seda; Yazgan, Burak; Gul, Melek; Yildirim, Tuba (Bentham Science Publ Ltd, 2022)
Background: Pyrrole compounds having a heterocyclic structure are the most researched and biological activities such as antioxidant and anticancer activities. Objective: Herein is a first effort to study the significance ...

Determination of biofilm formation, antibiotic susceptibility profiles and quorum sensing mediated virulence factors in ceftazidime resistant Pseudomonas aeruginosa 

Baskan, Ceren; Yildirim, Tuba; Bilgin, Melek; Sivas, Hulya (Springer, 2023)
This study aims to investigate the relationship between the antibiotic resistance, biofilm production, virulence factors, and quorum sensing systems of Pseudomonas aeruginosa. First, disc diffusion and microdilution tests ...

Synthesis, characterization and cytotoxic activity studies on cancer cell lines of new paraben-decorated monospiro-cyclotriphosphazenes 

Senkuytu, Elif; Akbas, Nadide; Yildirim, Tuba; Ciftci, Gonul Yenilmez (Royal Soc Chemistry, 2022)
Cancer is one of the Leading causes of death worldwide. Among the causes of cancer-related deaths in women, breast cancer, which is the most common type of cancer in women, is in second place. On the other hand, colon ...

The bioactive new type paraben decorated dispiro-cyclotriphosphaze compounds: synthesis, characterization and cytotoxic activity studies 

Senkuytu, Elif; Akbas, Nadide; Yildirim, Tuba; Ciftci, Gonul Yenilmez (Elsevier, 2022)
Cancer is a leading cause of death worldwide and hence studies to find anti-cancer agents for its treatment continue to grow in importance. Generally, cytotoxic drugs have been used for cancer treatment in susceptible ...
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Ciftci, Gonul Yenilmez (4)Mesci, Seda (4)Aksahin, Masuk (3)Baskan, Ceren (3)... View MoreSubjectapoptosis (2)Cyclotriphosphazene (2)cytotoxicity (2)RTCA (2)2-Hydroxyanthraquinone (1)... View MoreDate Issued2022 (5)2023 (4)2021 (3)Has File(s)No (12)

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